Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett

Andrew Huberman

Jul 2, 2026

Episode description

In this Huberman Lab Essentials episode, my guest is Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine, and an expert in hormone optimization. We discuss science-based tools for optimizing male hormones across the lifespan, including the role of bloodwork, nutrition, and exercise in supporting healthy hormone levels. We also discuss testosterone therapy, hair loss, prostate health, and supplements such as creatine, L-carnitine, Tongkat Ali, and Fadogia agrestis.

Show notes: https://go.hubermanlab.com/pBONCAb

Watch more Huberman Lab Essentials: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5

Timestamps
00:00:00 Kyle Gillett
00:00:20 Male Hormone Optimization, Testosterone, Tool: Blood Tests
00:02:17 Diet & Hormone Health, Diary, Vitamin D, Fiber
00:05:36 Caloric Restriction & Testosterone
00:06:44 Lifestyle Pillars: Stress, Life Purpose
00:07:56 Exercise & Hormone Health
00:08:59 Testosterone Replacement Therapy (TRT) & Young Adults
00:10:32 Supplements for Testosterone, Creatine & Hair Loss; Betaine, Doses
00:14:16 L-Carnitine, Forms, Dose, TMAO, Garlic & Berberine
00:17:29 Vitamin D, Boron
00:19:10 Tongkat Ali (Longjack); Fadogia Agrestis
00:23:56 Testosterone Therapy, Dose; Side Effects
00:28:32 Clomiphene, SERM & Testosterone
00:31:06 Alcohol, Aromatase & Testosterone
00:31:58 Prostate Health & Tadalafil, Nighttime Urination
00:33:59 Hair Loss, Caffeine, Finasteride, Dutasteride
00:36:02 Acknowledgements

#hubermanlab #science #health

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Mindsip insights from this episode:

Limit vigorous exercise to one hour for hormonal balance

It is not hormonally helpful to regularly train vigorously for longer than an hour.

#exercise

#hormones

Enhance androgen receptor density with L-carnitine and tadalafil

L-carnitine and tadalafil (Cialis) can increase the density of androgen receptors, making your existing testosterone more effective.

#supplement

#testosterone

Choose topical dutasteride for safer hair loss treatment

Topical dutasteride is a unique hair loss treatment that will not affect your systemic DHT levels, unlike topical finasteride which can lower it by 30%.

#DHT

#hair-loss

Utilize daily Cialis to enhance prostate health and reduce nighttime urination

A low daily dose of tadalafil (Cialis) is an underrated medication for improving prostate health and can cut nighttime urination episodes in half.

#prostate

Implement lower dose testosterone therapy for optimal results

A modern approach to testosterone therapy is a lower dose of around 100-120mg per week, divided into two or three smaller injections.

#testosterone

#TRT

Don't avoid creatine due to hair loss concerns

Hair loss is not a reason to avoid taking creatine, as it only brings you to what you are naturally inclined to have and won't speed up hair loss beyond that.