Doctors were Wrong about Cholesterol and Heart Disease
Physionic
Dec 29, 2025
Episode description
JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2
HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy
JOIN THE COMMUNITY
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2
EMAIL LIST
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6
HIRE ME FOR CONSULTING:
Consulting: https://bit.ly/3dmUl2H
Created with Biorender
Blood Pressure and Heart Disease: https://youtu.be/34cMamNp2Uo?si=uvV2yw0hcrLUDQZG
0:00 - Introduction
1:00 - Why Doctors were Wrong
1:49 - The First Wave of Evidence
3:55 - The Second Wave of Evidence
5:42 - HDL and Mortality, HDL Dysfunction
8:54 - How I'd Approach this
References
*Funding/Conflicts of Interest did not fit in the Description (there is a character limit); however, you can access both by joining my free email list or free Physionic Community
[1] Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977;62(5):707-714. doi:10.1016/0002-9343(77)90874-9
[Study 562] AIM-HIGH Investigators, Boden WE, Probstfield JL, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(24):2255-2267. doi:10.1056/NEJMoa1107579
[Study 563] HPS2-THRIVE Collaborative Group, Landray MJ, Haynes R, et al. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med. 2014;371(3):203-212. doi:10.1056/NEJMoa1300955
[Study 564] Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357(21):2109-2122. doi:10.1056/NEJMoa0706628
[Study 565] Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012;367(22):2089-2099.
[Study 566] Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380(9841):572-580. doi:10.1016/S0140-6736(12)60312-2
[Study 567] Holmes MV, Asselbergs FW, Palmer TM, et al. Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J. 2015;36(9):539-550. doi:10.1093/eurheartj/eht57
[Study 568] von Eckardstein A, Nordestgaard BG, Remaley AT, Catapano AL. High-density lipoprotein revisited: biological functions and clinical relevance. Eur Heart J. 2023;44(16):1394-1407. doi:10.1093/eurheartj/ehac605
CRITIQUES, RULES, AND NOTES
Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).
Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:
Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.
RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.
If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).
Please use the following link to submit your critique: https://bit.ly/PhysionicCritique
Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.
#hearthealth #heartdiseaseprevention
Mindsip insights from this episode:
Monitor HDL levels to mitigate death risk
Data reveals a U-shaped curve where both very low and very high HDL cholesterol levels are linked to an increased risk of death, acting as a 'yellow flag' for underlying issues.
Rethink high HDL cholesterol as heart attack risk factor
People with lifelong, genetically high HDL cholesterol levels do not have a lower risk of heart attack, confirming it is not inherently protective.
Reevaluate HDL's role in heart health
Multiple lines of evidence, including clinical trials and genetic studies, now prove that HDL is not the 'good cholesterol' it was once thought to be and does not directly protect the heart.
Prioritize HDL particle quality over cholesterol quantity
The emerging concept of 'HDL dysfunction' suggests the quality and function of the HDL particle itself is more important than the amount of cholesterol it contains.
Avoid drugs to raise HDL cholesterol for heart health
Pharmaceutical drugs designed specifically to raise 'good' HDL cholesterol failed to protect against heart disease, and some even caused increased harm and death.
View HDL cholesterol as a marker of overall health
Your HDL cholesterol number should be viewed as a marker of overall health rather than something to directly target with interventions.
More from
Physionic
This New Protein Study just Changed how we Think about Protein!
The One Breakfast Food that Eliminates Fat, Protects the Liver, and Builds Muscle!
The Liver Effect of using Wegovy and Ozempic that Researchers Didn’t Expect
The Crunchy Add-On Linked to Less Visceral Fat and Preserving your Brain
It Crushes Visceral Fat, But the Scale Barely Moves!
You also might be interested in
The Foods That Starve Cancer | William Li
Eating for Better Sleep & Foods that Improve Metabolic Health | Dr. Marie-Pierre St-Onge
Why Your Cholesterol Is High—and How to Start Fixing It in 10 Days
#395 - Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer's disease risk, and the effects of lipid-lowering therapies on brain health | Tom Dayspring, M.D.
Latest Seed Oil Controversy, Most Important Body Part?, CBN For Sleep & More! Solosode #501
