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Blood Pressure and Heart Disease: https://youtu.be/34cMamNp2Uo?si=uvV2yw0hcrLUDQZG

0:00 - Introduction
1:00 - Why Doctors were Wrong
1:49 - The First Wave of Evidence
3:55 - The Second Wave of Evidence
5:42 - HDL and Mortality, HDL Dysfunction
8:54 - How I'd Approach this

References
*Funding/Conflicts of Interest did not fit in the Description (there is a character limit); however, you can access both by joining my free email list or free Physionic Community

[1] Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977;62(5):707-714. doi:10.1016/0002-9343(77)90874-9

[Study 562] AIM-HIGH Investigators, Boden WE, Probstfield JL, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(24):2255-2267. doi:10.1056/NEJMoa1107579

[Study 563] HPS2-THRIVE Collaborative Group, Landray MJ, Haynes R, et al. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med. 2014;371(3):203-212. doi:10.1056/NEJMoa1300955

[Study 564] Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357(21):2109-2122. doi:10.1056/NEJMoa0706628

[Study 565] Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012;367(22):2089-2099.

[Study 566] Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380(9841):572-580. doi:10.1016/S0140-6736(12)60312-2

[Study 567] Holmes MV, Asselbergs FW, Palmer TM, et al. Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J. 2015;36(9):539-550. doi:10.1093/eurheartj/eht57

[Study 568] von Eckardstein A, Nordestgaard BG, Remaley AT, Catapano AL. High-density lipoprotein revisited: biological functions and clinical relevance. Eur Heart J. 2023;44(16):1394-1407. doi:10.1093/eurheartj/ehac605

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