Does Canola Oil cause Inflammation? Every RCT Analyzed. [Study 401-410 Analysis]

Physionic

Jun 28, 2025

Episode description

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0:00 - Introduction
2:03 - Topics Overview
3:17 - Immediate Measures of Inflammation
3:25 - Canola Oil on Inflammation in Women
19:48 - Long-Term Canola Oil Consumption on Inflammation
20:23 - Canola Oil on Ulcerative Colitis
26:45 - Canola Oil in Cardiovascular Disease
36:48 - Women with Diabetes and Canola Oil's Effects
44:50 - People with High Cholesterol
55:55 - Canola Oil in Overweight Individuals
1:04:07 - Canola Oil in Diabetes
1:10:08 - Canola Oil in Mildly Unhealthy Individuals
1:17:25 - Heated Canola Oil
1:30:52 - Mid-Point Conclusions/Main Points

References [NOTE: Funding and Conflicts of Interest information do not fit in the description box - I thought it would, please see the funding information displayed in the article in my Free version of the Physionic Community]

[Study 401] Nikooyeh B, Zargaraan A, Ebrahimof S, et al. Daily consumption of γ-oryzanol-fortified canola oil, compared with unfortified canola and sunflower oils, resulted in a better improvement of certain cardiometabolic biomarkers of adult subjects with type 2 diabetes: a randomized controlled clinical trial. Eur J Med Res. 2023;28(1):416. Published 2023 Oct 10. doi:10.1186/s40001-023-01409-8

[Study 402] Morvaridi M, Jafarirad S, Seyedian SS, Alavinejad P, Cheraghian B. The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis. Eur J Clin Nutr. 2020;74(6):891-899. doi:10.1038/s41430-019-0549-z

[Study 403] Khandouzi N, Zahedmehr A, Nasrollahzadeh J. Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography. Lipids Health Dis. 2020;19(1):183. Published 2020 Aug 14. doi:10.1186/s12944-020-01362-z

[Study 404] Atefi M, Pishdad GR, Faghih S. The effects of canola and olive oils on insulin resistance, inflammation and oxidative stress in women with type 2 diabetes: a randomized and controlled trial. J Diabetes Metab Disord. 2018;17(2):85-91. Published 2018 May 23. doi:10.1007/s40200-018-0343-9

[Study 405] Manning PJ, Sutherland WH, McGrath MM, de Jong SA, Walker RJ, Williams MJ. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring). 2008;16(9):2046-2052. doi:10.1038/oby.2008.334

[Study 406] Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJ. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr. 2011;105(3):417-427. doi:10.1017/S0007114510003697

[Study 407] Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity (Silver Spring). 2016;24(11):2261-2268. doi:10.1002/oby.21584

[Study 408] Perez-Herrera A, Delgado-Lista J, Torres-Sanchez LA, et al. The postprandial inflammatory response after ingestion of heated oils in obese persons is reduced by the presence of phenol compounds. Mol Nutr Food Res. 2012;56(3):510-514. doi:10.1002/mnfr.201100533

[Study 409] Haghighat N, Vafa M, Eghtesadi S, Heidari I, Hosseini A, Rostami A. The Effects of Tocotrienols Added to Canola Oil on Microalbuminuria, Inflammation, and Nitrosative Stress in Patients with Type 2 Diabetes: A Randomized, Double-blind, Placebo-controlled Trial. Int J Prev Med. 2014;5(5):617-623.

[Study 410] Ulven SM, Leder L, Elind E, et al. Exchanging a few commercial, regularly consumed food items with improved fat quality reduces total cholesterol and LDL-cholesterol: a double-blind, randomised controlled trial. Br J Nutr. 2016;116(8):1383-1393. doi:10.1017/S0007114516003445

********CRITIQUES, RULES, AND NOTES********

Critiques of my work are welcome! I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#canolaoil #inflammation

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
2:03 - Topics Overview
3:17 - Immediate Measures of Inflammation
3:25 - Canola Oil on Inflammation in Women
19:48 - Long-Term Canola Oil Consumption on Inflammation
20:23 - Canola Oil on Ulcerative Colitis
26:45 - Canola Oil in Cardiovascular Disease
36:48 - Women with Diabetes and Canola Oil's Effects
44:50 - People with High Cholesterol
55:55 - Canola Oil in Overweight Individuals
1:04:07 - Canola Oil in Diabetes
1:10:08 - Canola Oil in Mildly Unhealthy Individuals
1:17:25 - Heated Canola Oil
1:30:52 - Mid-Point Conclusions/Main Points

References [NOTE: Funding and Conflicts of Interest information do not fit in the description box - I thought it would, please see the funding information displayed in the article in my Free version of the Physionic Community]

[Study 401] Nikooyeh B, Zargaraan A, Ebrahimof S, et al. Daily consumption of γ-oryzanol-fortified canola oil, compared with unfortified canola and sunflower oils, resulted in a better improvement of certain cardiometabolic biomarkers of adult subjects with type 2 diabetes: a randomized controlled clinical trial. Eur J Med Res. 2023;28(1):416. Published 2023 Oct 10. doi:10.1186/s40001-023-01409-8

[Study 402] Morvaridi M, Jafarirad S, Seyedian SS, Alavinejad P, Cheraghian B. The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis. Eur J Clin Nutr. 2020;74(6):891-899. doi:10.1038/s41430-019-0549-z

[Study 403] Khandouzi N, Zahedmehr A, Nasrollahzadeh J. Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography. Lipids Health Dis. 2020;19(1):183. Published 2020 Aug 14. doi:10.1186/s12944-020-01362-z

[Study 404] Atefi M, Pishdad GR, Faghih S. The effects of canola and olive oils on insulin resistance, inflammation and oxidative stress in women with type 2 diabetes: a randomized and controlled trial. J Diabetes Metab Disord. 2018;17(2):85-91. Published 2018 May 23. doi:10.1007/s40200-018-0343-9

[Study 405] Manning PJ, Sutherland WH, McGrath MM, de Jong SA, Walker RJ, Williams MJ. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring). 2008;16(9):2046-2052. doi:10.1038/oby.2008.334

[Study 406] Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJ. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr. 2011;105(3):417-427. doi:10.1017/S0007114510003697

[Study 407] Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity (Silver Spring). 2016;24(11):2261-2268. doi:10.1002/oby.21584

[Study 408] Perez-Herrera A, Delgado-Lista J, Torres-Sanchez LA, et al. The postprandial inflammatory response after ingestion of heated oils in obese persons is reduced by the presence of phenol compounds. Mol Nutr Food Res. 2012;56(3):510-514. doi:10.1002/mnfr.201100533

[Study 409] Haghighat N, Vafa M, Eghtesadi S, Heidari I, Hosseini A, Rostami A. The Effects of Tocotrienols Added to Canola Oil on Microalbuminuria, Inflammation, and Nitrosative Stress in Patients with Type 2 Diabetes: A Randomized, Double-blind, Placebo-controlled Trial. Int J Prev Med. 2014;5(5):617-623.

[Study 410] Ulven SM, Leder L, Elind E, et al. Exchanging a few commercial, regularly consumed food items with improved fat quality reduces total cholesterol and LDL-cholesterol: a double-blind, randomised controlled trial. Br J Nutr. 2016;116(8):1383-1393. doi:10.1017/S0007114516003445

********CRITIQUES, RULES, AND NOTES********

Critiques of my work are welcome! I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#canolaoil #inflammation

Mindsip insights from this episode:

Clarify subclinical inflammation as oxidative stress damage

The term 'subclinical inflammation' is often used without a clear definition, but can be interpreted as cellular damage from oxidative stress, such as lipid peroxidation.

Pair fried foods with antioxidants to reduce inflammation

Consuming fried foods as part of a meal rich in antioxidants, such as lots of greens, may help counteract the potential inflammatory effects from the repeatedly heated oil.

Incorporate cold canola oil for potential anti-inflammatory benefits

Based on a comprehensive review of human intervention trials, consuming cold canola oil appears to be either neutral or beneficial for your inflammatory state.

Critique flawed heated oil study for accurate conclusions

The study on heated oil used a blend of 70% canola and 30% sunflower oil, making it difficult to isolate and blame canola oil alone for the negative results.

Understand limitations of heated oil study for home cooking

The only study showing negative effects used oil heated 20 times to 180°C (356°F), an extreme scenario more applicable to commercial deep fryers than typical home cooking.

Question dimethyl polysiloxane's antioxidant role in frying oils

A chemical called dimethyl polysiloxane is often added to commercial frying oils to reduce foaming, and while it has real-world applicability, its role as an antioxidant is questionable.

Critique short-term studies for meaningful health insights

The speaker criticizes one study as 'laughable' for attempting to measure artery plaque changes over just four weeks, a timeframe too short for meaningful results.

Utilize canola oil to reduce inflammation like olive oil

In a study on overweight women with type 2 diabetes, both canola and olive oil significantly reduced the key inflammatory marker C-reactive protein (CRP).

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