Does Vitamin D Supplementation actually improve Bone Health? [Study 329-333 Analysis]

Episode description

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Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

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0:00 - Introduction
1:34 - All Topics Covered
2:59 - Mechanisms of Action
3:02 - Study 332, Study 333
37:05 - Supplementing Vitamin D: Improve Bone Density?
37:29 - Study 329
53:11 - Study 330
1:06:30 - Does Vitamin D Supplementation reduce Fracture?
1:07:37 - Study 331
1:17:24 - Mid-Point Conclusion

References
[Study 329] Kazemian E, Pourali A, Sedaghat F, et al. Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis. Nutr Rev. 2023;81(5):511-530. doi:10.1093/nutrit/nuac068

Internal Funding: Alborz University of Medical Sciences // Conflict of Interest: One researcher is a consultant for Pharmaceutical

[Study 330] Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014;383(9912):146-155. doi:10.1016/S0140-6736(13)61647-5

Public Funding: Health Research Council of New Zealand // No Conflicts of Interest

[Study 331] Yao P, Bennett D, Mafham M, et al. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(12):e1917789. Published 2019 Dec 2. doi:10.1001/jamanetworkopen.2019.17789

Public Funding: Sin-British Fellowship Trust scholarship / One of the researchers is funded by the non-profit UK Medical Research Council

[Study 332] Li, Y., Zhao, P., Jiang, B. et al. Modulation of the vitamin D/vitamin D receptor system in osteoporosis pathogenesis: insights and therapeutic approaches. J Orthop Surg Res 18, 860 (2023). https://doi.org/10.1186/s13018-023-04320-4

Public Funding: High-end Foreign Expert Program of the Ministry of Science, China // No Conflicts of Interest

[Study 333] Nakamichi Y, Udagawa N, Suda T, Takahashi N. Mechanisms involved in bone resorption regulated by vitamin D. J Steroid Biochem Mol Biol. 2018;177:70-76. doi:10.1016/j.jsbmb.2017.11.005

Public Funding: Japan Society of the Promotion of Science // No Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#vitamind #bonehealth

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:34 - All Topics Covered
2:59 - Mechanisms of Action
3:02 - Study 332, Study 333
37:05 - Supplementing Vitamin D: Improve Bone Density?
37:29 - Study 329
53:11 - Study 330
1:06:30 - Does Vitamin D Supplementation reduce Fracture?
1:07:37 - Study 331
1:17:24 - Mid-Point Conclusion

References
[Study 329] Kazemian E, Pourali A, Sedaghat F, et al. Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis. Nutr Rev. 2023;81(5):511-530. doi:10.1093/nutrit/nuac068

Internal Funding: Alborz University of Medical Sciences // Conflict of Interest: One researcher is a consultant for Pharmaceutical

[Study 330] Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014;383(9912):146-155. doi:10.1016/S0140-6736(13)61647-5

Public Funding: Health Research Council of New Zealand // No Conflicts of Interest

[Study 331] Yao P, Bennett D, Mafham M, et al. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(12):e1917789. Published 2019 Dec 2. doi:10.1001/jamanetworkopen.2019.17789

Public Funding: Sin-British Fellowship Trust scholarship / One of the researchers is funded by the non-profit UK Medical Research Council

[Study 332] Li, Y., Zhao, P., Jiang, B. et al. Modulation of the vitamin D/vitamin D receptor system in osteoporosis pathogenesis: insights and therapeutic approaches. J Orthop Surg Res 18, 860 (2023). https://doi.org/10.1186/s13018-023-04320-4

Public Funding: High-end Foreign Expert Program of the Ministry of Science, China // No Conflicts of Interest

[Study 333] Nakamichi Y, Udagawa N, Suda T, Takahashi N. Mechanisms involved in bone resorption regulated by vitamin D. J Steroid Biochem Mol Biol. 2018;177:70-76. doi:10.1016/j.jsbmb.2017.11.005

Public Funding: Japan Society of the Promotion of Science // No Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#vitamind #bonehealth