Shocking Study Links MELATONIN to 89% Heart Failure Spike

Brad Stanfield

Nov 11, 2025

Episode description

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Timestamps:
00:00 New Melatonin & Heart Failure Study
03:29 Possible Explanation for the Association
04:18 Evidence from Randomized Controlled Trials
00:05:39 Concerns about Melatonin Supplements
06:44 Will Dr Brad Still Take Melatonin?

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Here are the links to the research papers referenced in the video:
https://eppro02.ativ.me/web/planner.php?id=AHA25
https://pmc.ncbi.nlm.nih.gov/articles/PMC8808329/
https://nerd.wwnorton.com/nerd/274511/r/goto/cfi/48!/4?demo=
https://jcsm.aasm.org/doi/10.5664/jcsm.11326
https://link.springer.com/article/10.1007/s11818-025-00495-6
https://pmc.ncbi.nlm.nih.gov/articles/PMC11873767/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9251346/
https://www.sciencedirect.com/science/article/abs/pii/S0022395619309872?via%3Dihub
https://pubmed.ncbi.nlm.nih.gov/33417003/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4138917
https://pubmed.ncbi.nlm.nih.gov/10883420/

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Episode description

Mindsip insights from this episode:

Question the validity of melatonin heart failure study results

A study linking melatonin to heart failure is questionable because the 'non-melatonin' control group likely included people taking it over-the-counter, contaminating the results.

#melatonin

#study

Take melatonin two hours before sleep for optimal effectiveness

As a 'chronobiotic agent', melatonin is most effective when taken about two hours before you want to fall asleep, giving it time to shift your sleep-wake cycle.

#melatonin

#sleep

Limit melatonin intake to avoid excessive doses

Many supplements contain over 5 milligrams of melatonin, which can deliver about 10 times the amount your body naturally produces at night.

#melatonin

#supplement

Address insomnia to improve heart health, not melatonin

The real cause of negative heart outcomes might be severe insomnia itself, not the melatonin prescribed to treat it, as poor sleep is causally linked to heart disease.

#heart

#insomnia

Choose 0.3 milligrams of melatonin for safer sleep support

A dose of 0.3 milligrams (300 micrograms) is a much safer alternative that sits right in the middle of the range your body normally produces.

#melatonin

#sleep

Leverage melatonin for heart health benefits

Contrary to recent headlines, multiple meta-analyses of randomized controlled trials found that melatonin is more likely to be beneficial for heart health.