Drown Cancer in This Nutrient – And Flip its Kill Switch

Physionic

Jul 28, 2025

Episode description

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0:00 - Introduction
2:53 - A Nutrient to the Rescue
3:59 - Nutrient that also increases Cancer??
4:40 - Stressing Cancer...
8:22 - Why the Paradox? And, what to do?
13:12 - Main Points

References
[Study 494] Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ. The Warburg effect dictates the mechanism of butyrate‑mediated histone acetylation and cell proliferation. Mol Cell. 2012 Nov 9;48(4):612–626. doi:10.1016/j.molcel.2012.08.033

Funding/Conflicts: Public Funding [This work was supported by grants from the National Cancer Institute (CA127445 and CA129286 to Y.C.) and the American Cancer Society (RSG-09-084-01-MGO to Y.C.)] // No direct Conflicts of Interest

[A] Wang T, Cai G, Qiu Y, et al. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J. 2012;6(2):320-329. doi:10.1038/ismej.2011.109

********CRITIQUES, RULES, AND NOTES********

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Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

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If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
2:53 - A Nutrient to the Rescue
3:59 - Nutrient that also increases Cancer??
4:40 - Stressing Cancer...
8:22 - Why the Paradox? And, what to do?
13:12 - Main Points

References
[Study 494] Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ. The Warburg effect dictates the mechanism of butyrate‑mediated histone acetylation and cell proliferation. Mol Cell. 2012 Nov 9;48(4):612–626. doi:10.1016/j.molcel.2012.08.033

Funding/Conflicts: Public Funding [This work was supported by grants from the National Cancer Institute (CA127445 and CA129286 to Y.C.) and the American Cancer Society (RSG-09-084-01-MGO to Y.C.)] // No direct Conflicts of Interest

[A] Wang T, Cai G, Qiu Y, et al. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J. 2012;6(2):320-329. doi:10.1038/ismej.2011.109

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Utilize butyrate to target cancer cells directly

Even at low concentrations, butyrate is harmful to cancer cells that rely on sugar because they bypass metabolizing it and it acts directly on their genes.

Implement butyrate-centric strategy to combat sugar-fed cancers

While a minority of cancers feed on fat, this butyrate-centric strategy seems useful for the majority of cancers that undergo the Warburg effect and feed on sugar.

Boost butyrate production with fiber-rich foods

You can increase butyrate production by eating dietary fiber-rich foods like green bananas, plantains, onions, garlic, and potatoes.

Investigate butyrate-producing bacteria in colorectal cancer patients

Human studies have identified that people with colorectal cancer tend to have fewer butyrate-producing bacteria compared to healthy individuals.

Boost p53 function with butyrate for cancer defense

Butyrate can increase the stability and DNA-binding ability of the powerful anti-tumor protein p53, enhancing its cancer-fighting function.

Utilize butyrate to alter cancer gene expression

Butyrate primarily harms cancer cells not by being a fuel source, but by changing gene expression through a process called histone acetylation.

Understand butyrate's dual role in cancer dynamics

The short-chain fat butyrate can stimulate cancer cells at low concentrations but stresses and kills them at high concentrations.

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