Hack Your Hunger: The Power of GLP-1 Probiotics - Colleen Cutcliffe, Ph.D.

Dave Asprey

Apr 11, 2024

Episode description

Join Dave Asprey for a fascinating discussion with Colleen Cutcliffe, Ph.D., on leveraging the power of GLP-1 for natural weight management and overall well-being. Discover how probiotics can naturally stimulate GLP-1 production in the body, helping reduce food cravings and maintain a healthy gut lining. We delve into the differences between pharmaceuticals and natural probiotics, the importance of GLP-1 for longevity, and practical tips for optimizing your microbiome health. Whether you're battling cravings or seeking to prevent diabetes and its associated risks, this episode sheds light on natural, effective strategies for a healthier life. 



Timestamp Highlights: 

(00:00:01) Introduction to GLP-1 and weight management 

(00:01:06) Colleen Cutcliffe, PhD, on natural ways to stimulate GLP-1 

(00:04:41) The role of microbiome in regulating GLP-1 and cravings 

(00:16:00) The GLP-1 probiotic: benefits beyond weight loss 

(00:34:13) Dietary interventions to support GLP-1 probiotics 

(00:42:23) Personal experiences and results with GLP-1 probiotics 

(00:51:01) The different pendulum products and who should take them 

(00:59:23) How GLP-1 probiotics impact the gut lining and overall health 

(01:03:56) GLP-1 and its connection to longevity and disease prevention 



Sponsors: 

Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20 

ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off 

ARRC LED | For More Information Visit ARRCLED.com 



Resources: 

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books  

Instagram: @Dave.Asprey 

Pendulum GLP-1 Probiotics: https://pendulumlife.com (Code: Asprey20 for 20% off) 

Instagram: @pendulumlifeco

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episode description

Join Dave Asprey for a fascinating discussion with Colleen Cutcliffe, Ph.D., on leveraging the power of GLP-1 for natural weight management and overall well-being. Discover how probiotics can naturally stimulate GLP-1 production in the body, helping reduce food cravings and maintain a healthy gut lining. We delve into the differences between pharmaceuticals and natural probiotics, the importance of GLP-1 for longevity, and practical tips for optimizing your microbiome health. Whether you're battling cravings or seeking to prevent diabetes and its associated risks, this episode sheds light on natural, effective strategies for a healthier life. 



Timestamp Highlights: 

(00:00:01) Introduction to GLP-1 and weight management 

(00:01:06) Colleen Cutcliffe, PhD, on natural ways to stimulate GLP-1 

(00:04:41) The role of microbiome in regulating GLP-1 and cravings 

(00:16:00) The GLP-1 probiotic: benefits beyond weight loss 

(00:34:13) Dietary interventions to support GLP-1 probiotics 

(00:42:23) Personal experiences and results with GLP-1 probiotics 

(00:51:01) The different pendulum products and who should take them 

(00:59:23) How GLP-1 probiotics impact the gut lining and overall health 

(01:03:56) GLP-1 and its connection to longevity and disease prevention 



Sponsors: 

Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20 

ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off 

ARRC LED | For More Information Visit ARRCLED.com 



Resources: 

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books  

Instagram: @Dave.Asprey 

Pendulum GLP-1 Probiotics: https://pendulumlife.com (Code: Asprey20 for 20% off) 

Instagram: @pendulumlifeco

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mindsip insights from this episode:

Utilize three-strain GLP-1 formula to enhance gut health

The GLP-1 probiotic formula combines Akkermansia muciniphila and Clostridium butyricum, the only two strains published to increase GLP-1, with Bifidobacterium infantis to support their function.

Reduce food cravings by 91% with GLP-1 probiotic

In a six-week study, 91% of people taking the GLP-1 probiotic had a statistically significant reduction in food cravings for sugars, carbs, fast foods, and high-fat foods.

Detach identity from body to empower change without shame

Detaching your identity from your body's biological state, like food cravings, is an empowering mental shift that allows you to fix the problem without shame.

Focus on cravings reduction for effective body recomposition

The goal should be reducing cravings to enable better food choices and body recomposition, like converting fat to muscle, not just weight loss, which can be a problematic metric.

Avoid two-day-old leftovers to prevent blood sugar spikes

Two-day-old leftovers, particularly with protein like chicken, can cause a significant blood sugar spike due to the growth of histamine, which acts as a stressor on the body.

Leverage Akkermansia muciniphila for blood sugar control and gut health

The strain Akkermansia muciniphila not only stimulates GLP-1 for blood sugar control but also strengthens the gut lining by regulating the mucin layer, which can reduce inflammation.

Biohack by aggressively testing solutions before finding minimum effective dose

The most effective biohacking strategy is to throw everything that might work at a problem to get results, and only then start backing off to find the minimum effective dose.

Boost longevity with Akkermansia muciniphila probiotic strain

People who live to be over 100 years old have been found to have a ton of the probiotic strain Akkermansia muciniphila in their gut.

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© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius