‘High Dose Vitamin D’s Steroid-like Effect! Crazy!’

Physionic

Mar 21, 2026

Episode description

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0:00 - Introduction
0:52 - Vitamin D on Muscle and Metabolism Hormones
6:06 - More Vitamin D, More Muscle
8:33 - Boosts in Metabolism!
13:40 - More Vitamin D, More Muscle, More Height?
17:27 - Supplementing Vitamin D, Glycine, Magnesium
20:56 - Main Points

Original Video: https://www.youtube.com/watch?v=a1fOBOD4CJc

References
[1] Flier JS, Ahima RS. Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery. J Clin Invest. 2024;134(1):e174595. doi:10.1172/JCI174595.

[2] Baig MH, Ahmad K, Moon JS, et al. Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies. Front Physiol. 2022;13:876078. Published 2022 Jun 23. doi:10.3389/fphys.2022.876078

[3] Roizen J, Long C, Casella A, Nguyen M, Danahy L, Seiler C, Lei M, Mark J. High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling. Research Square [preprint]. Published May 8, 2024. doi:10.21203/rs.3.rs-4202165/v1

[4] Romeu Montenegro K, Maron Carlessi R, Fernandes Cruzat V, Newsholme P. Effects of vitamin D on primary human skeletal muscle cell proliferation, differentiation, protein synthesis and bioenergetics. J Steroid Biochem Mol Biol. 2019;195:105423. doi:10.1016/j.jsbmb.2019.105423.

[5] Bass JJ, Nakhuda A, Deane CS, Brook MS, Wilkinson DJ, Phillips BE, Philp A, Tarum J, Kadi F, Andersen D, Muñoz Garcia A, Smith K, Gallagher IJ, Szewczyk NJ, Cleasby ME, Atherton PJ. Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy. Mol Metab. 2020;42:101059. doi:10.1016/j.molmet.2020.101059.

[6] Agergaard J, Trøstrup J, Uth J, et al. Does vitamin-D intake during resistance training improve the skeletal muscle hypertrophic and strength response in young and elderly men? A randomized controlled trial. Nutr Metab (Lond). 2015;12:32. doi:10.1186/s12986-015-0029-y

[7] Ceglia L, Niramitmahapanya S, da Silva Morais M, et al. A randomized study on the effect of vitamin D₃ supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab. 2013;98(12):E1927-E1935. doi:10.1210/jc.2013-2820

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Question the leap from childhood height data to adult muscle growth

Using genetic data that links vitamin D to height in growing children as evidence for muscle growth in adults is a significant and potentially flawed scientific leap.

#genetics

#muscle

Question validity of unpublished vitamin D study

The mouse study central to these claims has not passed peer review and has been an unpublished preprint for almost two years.

#research

#vitamin-D

Redirect calories from fat to muscle with high-dose vitamin D

High-dose vitamin D may cause the body to redirect calories from fat storage toward muscle construction without changes in diet or activity.

#muscle

#vitamin-D

Test blood regularly when increasing vitamin D dosage

If you are increasing your vitamin D dosage, you should get a blood test every two to four weeks to ensure you don't reach toxic levels.

#blood-test

#vitamin-D

Enhance vitamin D levels to boost muscle and fat hormone balance

Raising vitamin D from normal to high may increase leptin sensitivity while suppressing myostatin, shifting the body from a 'store and preserve' mode to a 'build and repair' mode.

#muscle

#vitamin-D

Leverage genetics to enhance vitamin D and growth potential

People with genetic variants that naturally increase their vitamin D levels also tend to be taller, suggesting a metabolism that is more growth-oriented.