How Fasting Can Support Hormones, Muscle, And Heal The Body

Mark Hyman

Mar 27, 2024

Episode description

There’s been a lot of recent discussion around fasting, and for good reason. But one thing that often slips through the cracks is the differences between men and women, and why women need to take a specific approach to fasting that honors their hormones. You may have heard the recent buzz around fasting and a controversial headline associating it with cardiovascular death (which was not peer-reviewed, by the way). So today, I’m resharing this popular episode with holistic health expert Dr. Mindy Pelz to shed light on what we really know about the safety of fasting, and the dos and don’ts, particularly for women.



We discuss:

  • Will time-restricted eating kill you? Deciphering recent headlines

  • Two major issues happening for women: Understanding hormone cycles and an evolutionary mismatch 

  • Mindy’s expert approach to managing hormones through fasting 

  • Three rules for successfully reintroducing foods 

  • Who should avoid fasting?

  • Tips for women over 40 that aren’t being talked about 

  • The best way to get a handle on hormone testing



Fasting can be an incredibly healing practice, but it’s got to be done the right way—especially for women! Learn how to fast while supporting hormonal balance, and so much more, in this episode with Dr. Mindy Pelz. 



This episode is brought to you by LMNT, BIOptimizers, Thrive Market, and Happy Egg.



LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today.



Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10%.



Head over to thrivemarket.com/Hyman today to received 30% off your first order and a free gift up to $60.



Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit happyegg.com/farmacy to find Happy Egg near you.

Episode description

There’s been a lot of recent discussion around fasting, and for good reason. But one thing that often slips through the cracks is the differences between men and women, and why women need to take a specific approach to fasting that honors their hormones. You may have heard the recent buzz around fasting and a controversial headline associating it with cardiovascular death (which was not peer-reviewed, by the way). So today, I’m resharing this popular episode with holistic health expert Dr. Mindy Pelz to shed light on what we really know about the safety of fasting, and the dos and don’ts, particularly for women.



We discuss:

  • Will time-restricted eating kill you? Deciphering recent headlines

  • Two major issues happening for women: Understanding hormone cycles and an evolutionary mismatch 

  • Mindy’s expert approach to managing hormones through fasting 

  • Three rules for successfully reintroducing foods 

  • Who should avoid fasting?

  • Tips for women over 40 that aren’t being talked about 

  • The best way to get a handle on hormone testing



Fasting can be an incredibly healing practice, but it’s got to be done the right way—especially for women! Learn how to fast while supporting hormonal balance, and so much more, in this episode with Dr. Mindy Pelz. 



This episode is brought to you by LMNT, BIOptimizers, Thrive Market, and Happy Egg.



LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today.



Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10%.



Head over to thrivemarket.com/Hyman today to received 30% off your first order and a free gift up to $60.



Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit happyegg.com/farmacy to find Happy Egg near you.

Mindsip insights from this episode:

Utilize Dutch test for comprehensive hormone analysis in cycling women

For cycling women, a urinary Dutch test is superior to a blood test because it shows how estrogen is being broken down (metabolites), not just the total level.

Disregard flawed study linking time-restricted eating to heart attack risk

A recent study claiming a 91% increased heart attack risk from time-restricted eating was based on unreliable, sloppy data and should not be used to scare people away from the practice.

Manage stress to support progesterone levels

The hormone progesterone, which is dominant the week before a period, is very sensitive to cortisol, so when cortisol from stress goes high, progesterone levels drop.

Vary fasting according to menstrual cycle to balance hormones

Continuously fasting one meal a day can destroy women's hormones; instead, fasting should be varied according to the menstrual cycle to balance estrogen and progesterone.

Reboot dopamine system with a 48-hour fast

Fasting for 48 hours can reboot the dopamine system by creating new receptor sites, allowing you to get more pleasure from less food.

Refeed after fasting to rebuild stronger muscle

While fasting can cause temporary muscle breakdown, the refeeding period is a powerful opportunity to rebuild muscle stronger by consuming at least 30 grams of protein every few hours.

Implement 5-1-1 fasting schedule for optimal health

For men and post-menopausal women, a recommended weekly schedule is five days of intermittent fasting, one day of a longer fast, and one day of feasting with no fasting.

Limit fasting to 15 hours for nursing mothers' health

Nursing mothers should not fast longer than 15 hours because toxins released from cells during autophagy can pass into their breast milk.

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© Mindsip 2025 – Made with ❤ in Vilnius

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© Mindsip 2025 – Made with ❤ in Vilnius