How ‘Healthy’ Gut Habits Are Making Cancer Worse

Physionic

Jul 7, 2025

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:13 - Responders vs Non-Responders
3:03 - Gut Health Supplement vs Cancer Progression
5:05 - A Second Gut Health Supplement vs Cancer Progression
7:15 - Important things you should know...
8:40 - Main Points

Reference
[Study 483] Spencer CN, McQuade JL, Gopalakrishnan V, et al. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science. 2021;374(6575):1632-1640. doi:10.1126/science.aaz7015

Funding/Conflicts: Public funding was provided by the U.S. National Institutes of Health (e.g., R01 CA219896–01A1, R01AI109294), the U.S. Department of Defense (W81XWH‑16‑1‑0121), the Cancer Prevention and Research Institute of Texas (e.g., RP170067, RP210028, RP160097), the U.S.–Israel Binational Science Foundation (201332), and the NCI Cancer Center Support Grant (P30 CA016672); Non‑profit/philanthropic funding came from the Melanoma Research Alliance (4022024, 564449), the American Association for Cancer Research–Stand Up To Cancer (SU2C‑AACR‑IRG‑19‑17), the Parker Institute for Cancer Immunotherapy, the Melanoma Moon Shots Program at MD Anderson, the Mark and Seerave Foundations, the American Society of Clinical Oncology/Conquer Cancer Foundation, the Elkins and Rising Tide Foundations, the Longenbaugh‑Torian Fund, the Andrew Sabin Family Fellows Program, Cancer Fighters of Houston, and various institutional research training and fellowship awards. // Potential direct Conflicts of Interest: Competing interests include several patent applications and inventor credits: J.A.W., V.G., and M.C.A. are inventors on patent WO2020106983A1 covering methods and compositions for cancer treatment and prediction of checkpoint inhibitor response; J.A.W. and V.G. on a US patent application (PCT/US17/53717) for enhancing ICB responses via microbiome modulation; J.A.W. and R.R.J. on patent WO2020150429A1 relating to ICI‑associated colitis; R.R.J. on additional patents WO2016086161A1 and WO2017041039A1 for microbiome‑based therapies. J.A.W. also receives honoraria and consulting fees from multiple biopharmaceutical companies (e.g., Roche/Genentech, Novartis, AstraZeneca, Bristol‑Myers Squibb, Merck) and research support from GSK, Roche/Genentech, BMS, and Novartis. Other authors report advisory roles, honoraria, equity holdings, or research funding from industry partners including MSD Australia, Immunai, Vastbiome, Seres Therapeutics, Kaleido Biosciences, and more


********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#probiotics #fiber #cancerawareness

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:13 - Responders vs Non-Responders
3:03 - Gut Health Supplement vs Cancer Progression
5:05 - A Second Gut Health Supplement vs Cancer Progression
7:15 - Important things you should know...
8:40 - Main Points

Reference
[Study 483] Spencer CN, McQuade JL, Gopalakrishnan V, et al. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science. 2021;374(6575):1632-1640. doi:10.1126/science.aaz7015

Funding/Conflicts: Public funding was provided by the U.S. National Institutes of Health (e.g., R01 CA219896–01A1, R01AI109294), the U.S. Department of Defense (W81XWH‑16‑1‑0121), the Cancer Prevention and Research Institute of Texas (e.g., RP170067, RP210028, RP160097), the U.S.–Israel Binational Science Foundation (201332), and the NCI Cancer Center Support Grant (P30 CA016672); Non‑profit/philanthropic funding came from the Melanoma Research Alliance (4022024, 564449), the American Association for Cancer Research–Stand Up To Cancer (SU2C‑AACR‑IRG‑19‑17), the Parker Institute for Cancer Immunotherapy, the Melanoma Moon Shots Program at MD Anderson, the Mark and Seerave Foundations, the American Society of Clinical Oncology/Conquer Cancer Foundation, the Elkins and Rising Tide Foundations, the Longenbaugh‑Torian Fund, the Andrew Sabin Family Fellows Program, Cancer Fighters of Houston, and various institutional research training and fellowship awards. // Potential direct Conflicts of Interest: Competing interests include several patent applications and inventor credits: J.A.W., V.G., and M.C.A. are inventors on patent WO2020106983A1 covering methods and compositions for cancer treatment and prediction of checkpoint inhibitor response; J.A.W. and V.G. on a US patent application (PCT/US17/53717) for enhancing ICB responses via microbiome modulation; J.A.W. and R.R.J. on patent WO2020150429A1 relating to ICI‑associated colitis; R.R.J. on additional patents WO2016086161A1 and WO2017041039A1 for microbiome‑based therapies. J.A.W. also receives honoraria and consulting fees from multiple biopharmaceutical companies (e.g., Roche/Genentech, Novartis, AstraZeneca, Bristol‑Myers Squibb, Merck) and research support from GSK, Roche/Genentech, BMS, and Novartis. Other authors report advisory roles, honoraria, equity holdings, or research funding from industry partners including MSD Australia, Immunai, Vastbiome, Seres Therapeutics, Kaleido Biosciences, and more


********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#probiotics #fiber #cancerawareness

Mindsip insights from this episode:

Evaluate probiotics for personalized health benefits

A supplement like probiotics can be beneficial in some contexts but may be harmful in specific situations, highlighting that not all good things are universally good.

Pair dietary fiber with anti-cancer immunotherapy to halt tumor progression

Dietary fiber may unlock the effectiveness of anti-cancer immunotherapy, as it completely stopped tumor progression when paired with treatment in a mouse model.

Avoid probiotics during immunotherapy for late-stage cancer patients

In a study of late-stage cancer patients on immunotherapy, those consuming probiotics appeared to have a greater risk of cancer progression.

Increase fiber intake to slow cancer progression

A study on melanoma patients found a clear and statistically significant link between higher dietary fiber intake and much less cancer progression.

Avoid probiotics to prevent tumor growth

In a mouse study, giving probiotics to mice with human gut bacteria resulted in a nearly ten-fold increase in tumor size compared to the control group.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius