How much does Reversing Plaque lower your Heart Attack risk?

Physionic

Apr 25, 2025

Episode description

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0:00 - Introduction
0:16 - The Study
0:59 - Plaque Characteristics that make a Difference
2:26 - The Results
4:32 - Important Considerations...
5:49 - Main Points

Reference
[Study 440] Iatan I, Guan M, Humphries KH, Yeoh E, Mancini GBJ. Atherosclerotic Coronary Plaque Regression and Risk of Adverse Cardiovascular Events: A Systematic Review and Updated Meta-Regression Analysis. JAMA Cardiol. 2023;8(10):937-945. doi:10.1001/jamacardio.2023.2731

Funding/Conflicts: Unknown Funding / Potential direct Conflicts of Interest [Dr. Mancini disclosed receiving advisory board fees from Amgen, Sanofi, HLS Therapeutics, Esperion, and Novartis. He also reported receiving continuing medical education (CME) lecture fees from Amgen, Sanofi, HLS Therapeutics, and Novartis. Additionally, he received research grants from Novartis unrelated to the submitted work. No other authors reported any disclosures or conflicts of interest.]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cardiovasculardisease #heartdiseaseprevention

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:16 - The Study
0:59 - Plaque Characteristics that make a Difference
2:26 - The Results
4:32 - Important Considerations...
5:49 - Main Points

Reference
[Study 440] Iatan I, Guan M, Humphries KH, Yeoh E, Mancini GBJ. Atherosclerotic Coronary Plaque Regression and Risk of Adverse Cardiovascular Events: A Systematic Review and Updated Meta-Regression Analysis. JAMA Cardiol. 2023;8(10):937-945. doi:10.1001/jamacardio.2023.2731

Funding/Conflicts: Unknown Funding / Potential direct Conflicts of Interest [Dr. Mancini disclosed receiving advisory board fees from Amgen, Sanofi, HLS Therapeutics, Esperion, and Novartis. He also reported receiving continuing medical education (CME) lecture fees from Amgen, Sanofi, HLS Therapeutics, and Novartis. Additionally, he received research grants from Novartis unrelated to the submitted work. No other authors reported any disclosures or conflicts of interest.]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cardiovasculardisease #heartdiseaseprevention

Mindsip insights from this episode:

Achieve 1% plaque reduction to lower cardiovascular event risk by 19%

After adjusting for factors like age, LDL, and blood pressure, a 1% reversal in arterial plaque volume is associated with a 19% reduction in cardiovascular event risk.

Recognize true risk reduction from reversing plaque exceeds 19%

The true risk reduction from reversing plaque may be even greater than 19% because many studies compared treatments against low-dose statins, not a true placebo.

Address inflammation to stabilize plaque and reduce rupture risk

A major component of dangerous plaque is the inflammatory 'necrotic core' formed by dead immune cells, which destabilizes the plaque and makes it more likely to rupture.

Monitor fibrotic cap thickness to assess plaque risk

The thickness of the fibrotic cap that cells place on top of plaque is a key risk factor, as a thinner cap is more prone to breaking than a thicker one.

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