I Made Myself Older By Mistake

Bryan Johnson

Mar 31, 2025

Episode description

On September 28th, I decided to stop taking Rapamycin. Here's the full story.

🥦 Order my Blueprint Stack: https://blueprint.bryanjohnson.com/collections/all-products
📩 Subscribe for my latest protocols: https://dontdie.bryanjohnson.com/

Relevant Rapamycin studies

2002: https://pubmed.ncbi.nlm.nih.gov/12177161/
2012: https://pmc.ncbi.nlm.nih.gov/articles/PMC3384435
2008: https://pmc.ncbi.nlm.nih.gov/articles/PMC4084728
2013: https://diabetesjournals.org/diabetes/article/62/8/2674/34093/Evidence-for-Rapamycin-Toxicity-in-Pancreatic
2024: https://www.biorxiv.org/content/10.1101/2024.10.22.619522v1.full.pdf

Let’s be friends:
Twitter: https://x.com/bryan_johnson
Instagram: https://www.instagram.com/bryanjohnson_
TikTok: https://www.tiktok.com/@_bryan_johnson_

Project Blueprint and Don’t Die celebrate that we, humanity, are evolving into something new. Join me on this journey.

Mindsip insights from this episode:

Identify personal side effects of Rapamycin for informed decisions

The speaker personally experienced side effects from Rapamycin including mouth canker sores, slow wound healing, cholesterol disruptions, and an increased resting heart rate.

#rapamycin

#side-effects

Combine Rapamycin and Acarbose to enhance mouse longevity

In mice, combining Rapamycin with the drug Acarbose showed even greater longevity benefits, increasing lifespan by up to 34% in males.

#longevity

#rapamycin

Inhibit mTORC1 aging pathway through caloric restriction, fasting, and exercise

You can naturally inhibit the mTORC1 aging pathway, the same one targeted by Rapamycin, through caloric restriction, fasting, and exercise.

#longevity

#mTOR

Reevaluate rapamycin's impact on aging acceleration

A recent preprint paper showed that Rapamycin, a drug taken for longevity, actually accelerated the biological speed of aging in humans across 16 epigenetic clocks.

#aging

#rapamycin

Balance rapamycin use to maximize longevity benefits and minimize side effects

Rapamycin inhibits the mTORC1 pathway for longevity benefits, but it also inhibits mTORC2, which is linked to negative side effects like metabolic dysfunction.

#longevity

#rapamycin

Beware rapamycin's risk of suppressing cancer-fighting NK cells

A major risk of Rapamycin is that it suppresses the immune system, specifically your Natural Killer (NK) cells, which are your body's cancer-fighting cells.

#cancer

#rapamycin

Evaluate experimental drugs as calculated risks in aging

The speaker views taking experimental drugs as a calculated risk, just as eating fast food or getting poor sleep are known risks that accelerate your speed of aging.