The speaker personally experienced side effects from Rapamycin including mouth canker sores, slow wound healing, cholesterol disruptions, and an increased resting heart rate.

In mice, combining Rapamycin with the drug Acarbose showed even greater longevity benefits, increasing lifespan by up to 34% in males.

You can naturally inhibit the mTORC1 aging pathway, the same one targeted by Rapamycin, through caloric restriction, fasting, and exercise.

A recent preprint paper showed that Rapamycin, a drug taken for longevity, actually accelerated the biological speed of aging in humans across 16 epigenetic clocks.

Rapamycin inhibits the mTORC1 pathway for longevity benefits, but it also inhibits mTORC2, which is linked to negative side effects like metabolic dysfunction.

A major risk of Rapamycin is that it suppresses the immune system, specifically your Natural Killer (NK) cells, which are your body's cancer-fighting cells.

The speaker views taking experimental drugs as a calculated risk, just as eating fast food or getting poor sleep are known risks that accelerate your speed of aging.