The Truth About What’s Failing in Longevity Science

Brad Stanfield

Oct 31, 2025

Episode description

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Here are the links to the research papers referenced in the video:

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

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Mindsip insights from this episode:

Leverage next-gen peptides for enhanced weight loss

Newer drugs like Tirzepatide and Retatrutide, which combine multiple peptides, offer even greater weight loss effects than single GLP1 medications.

#peptides

#weight-loss

Explore microdosing GLP1 medications for health and lifespan benefits

An interesting new hypothesis is whether microdosing GLP1 medications in healthy individuals could offer health and lifespan benefits.

#GLP1

#microdosing

Learn from resveratrol research failure to guide future investments

GSK invested $720 million in resveratrol research based on initial hype, but the results could not be replicated, leading to a total loss.

#research

Utilize canagliflozin to extend lifespan in type 2 diabetes management

The SGLT2 inhibitor canagliflozin, a medication for type 2 diabetes, was found to extend male mice lifespan by 14% in a robust study.

#lifespan

#SGLT2

Reject popular supplements that fail lifespan tests

The rigorous Interventions Testing Program found that neither the senolytic fisetin nor the NAD precursor nicotinamide riboside (NR) extended lifespan in mice.

#lifespan

#supplement

Leverage rapamycin to enhance lifespan by up to 25%

Rapamycin is considered the 'golden child' of longevity research, as it consistently extends both male and female mice lifespan by 17% to 25%.

#longevity

#rapamycin

Receive twice-a-year cholesterol shot to lower LDL by 50%

New small interfering PCSK9 inhibitors can lower LDL cholesterol by about 50% with just one injection every six months, dramatically improving adherence.

#cholesterol

#LDL

Choose non-ablative lasers for effective skin aging treatment

Modern non-ablative skin devices offer nearly the same reduction in fine lines and wrinkles as older ablative lasers but without the significant recovery time.