Is Red Meat the Fountain of Youth? Paul Saladino
Dave Asprey
Dec 5, 2024
Episode description
Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?
Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity.
They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter.
What you’ll learn:
• Why metabolic flexibility matters more than strict diet rules
• The science behind long-term ketosis and insulin’s broader role in health
• How common “health foods” could be doing more harm than good
• The importance of nutrient-dense animal-based foods for gut and immune health
• How to achieve optimal balance between fat types, mTOR, and longevity markers
Resources:
2025 Biohacking Conference – https://biohackingconference.com/2025
Shop Paul Saladino’s Products – https://heartandsoil.co
Follow Paul Saladino on Instagram – https://www.instagram.com/paulsaladinomd/
Paul Saladino’s Book: The Carnivore Code – https://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X
Lineage Provisions – 100% Grass-Fed Beef Tallow – https://lineageprovisions.com/products/100-grass-fed-beef-tallow
Danger Coffee – https://dangercoffee.com
Danger Coffee Instagram – https://www.
Mindsip insights from this episode:
Consume organs to harness healing signaling molecules
The benefits of eating organs may come from signaling molecules like microRNAs that support the corresponding organ, not just from their nutrient content.
Avoid fast-food french fries to reduce cancer risk
A large serving of fast-food french fries contains an amount of carcinogenic oxidation products equivalent to smoking 25 cigarettes.
Protect cells from seed oil damage with dairy fat
Odd-chain fatty acids found in dairy fat, like C15, may protect your cells from a type of cell death (ferroptosis) caused by seed oil consumption.
Challenge the assumption that high LDL causes arterial plaque
In a study of lean individuals on keto diets, there was zero correlation between extremely high LDL levels (average 273) and the amount of arterial plaque.
Commit to a decade-long detox from seed oils
Because the half-life of fat in your cell membranes is over two years, it can take nearly a decade to fully remodel your cells after you stop eating seed oils.
Beware downsides of strict carnivore diet on health
A strict meat, organs, and salt diet can lead to electrolyte insufficiency, heart palpitations, and a significant drop in testosterone.
Recognize insulin spikes as beneficial for electrolyte retention
Post-meal insulin spikes are beneficial and signal the kidneys to retain essential electrolytes like sodium, potassium, and magnesium.
Limit oxalates in smoothies to avoid toxicity
A single spinach and kale smoothie can contain five times the amount of oxalates your body can eliminate in a day.
Focus on food quality, not calorie counting
The concept of 'calories in, calories out' is a distraction from food quality, potentially promoted by big food companies to sell processed foods.
Avoid oatmeal to preserve your body's minerals
Due to remaining phytic acid even after cooking, every bowl of oatmeal you eat chelates and removes minerals from your body.
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