Master Neuroplasticity to Improve Your Life - Nicole Vignola

Dave Asprey

Jun 6, 2024

Episode description

In this episode, Nicole Vignola, a neuroscientist with a BS in Neuroscience and a Master of Science in Organizational Psychology, explains how to rewire the brain for better decision-making and lasting change. You will learn about neuroplasticity, the science behind creating and undoing brain pathways, and practical strategies for forming new habits. Nicole shares the importance of visualization, taking strategic breaks, and focusing on strengths rather than weaknesses. She discusses the concept of mental currency and how to allocate energy effectively. 

The episode also covers how to manage negative thoughts, boost positive thinking, and the role of myelination in habit formation. Nicole explains how to use visualization paired with physical activity to reinforce new habits and prepare for setbacks. This episode provides actionable advice for anyone looking to improve mental health, enhance cognitive function, and create lasting positive changes in their life. 

Nicole’s new book, “Rewire: Break the Cycle, Alter Your Thoughts and Create Lasting Change (Your Neurotoolkit for Everyday Life)” is out now! 



Timestamps:

  • (00:01:02) Introduction to Nicole Vignola and her work 

  • (00:01:44) The importance of affirmations and voice modulation 

  • (00:06:31) Fundamentals of neuroplasticity 

  • (00:09:42) The future of neuron regeneration 

  • (00:13:54) Habits, myelination, and cognitive energy 

  • (00:19:03) Mental currency and vigilance decrement 

  • (00:23:32) Trying harder vs. strategic rest 

  • (00:28:05) Morning vs. evening energy dynamics 

  • (00:29:24) The role of strategic breaks 

  • (00:31:27) Focusing on strengths over weaknesses 

  • (00:35:59) Managing negative thoughts and default mode network 

  • (00:43:03) Tools for creating positive thoughts 

  • (00:47:39) Healing trauma and synaptic rewiring 

  • (00:50:58) Gratitude practice and neuroplasticity 

  • (00:55:31) Longevity and healthy aging 

  • (01:01:20) Nicole's perspective on living past 100 



Sponsors: 



Resources: 

Episode description

In this episode, Nicole Vignola, a neuroscientist with a BS in Neuroscience and a Master of Science in Organizational Psychology, explains how to rewire the brain for better decision-making and lasting change. You will learn about neuroplasticity, the science behind creating and undoing brain pathways, and practical strategies for forming new habits. Nicole shares the importance of visualization, taking strategic breaks, and focusing on strengths rather than weaknesses. She discusses the concept of mental currency and how to allocate energy effectively. 

The episode also covers how to manage negative thoughts, boost positive thinking, and the role of myelination in habit formation. Nicole explains how to use visualization paired with physical activity to reinforce new habits and prepare for setbacks. This episode provides actionable advice for anyone looking to improve mental health, enhance cognitive function, and create lasting positive changes in their life. 

Nicole’s new book, “Rewire: Break the Cycle, Alter Your Thoughts and Create Lasting Change (Your Neurotoolkit for Everyday Life)” is out now! 



Timestamps:

  • (00:01:02) Introduction to Nicole Vignola and her work 

  • (00:01:44) The importance of affirmations and voice modulation 

  • (00:06:31) Fundamentals of neuroplasticity 

  • (00:09:42) The future of neuron regeneration 

  • (00:13:54) Habits, myelination, and cognitive energy 

  • (00:19:03) Mental currency and vigilance decrement 

  • (00:23:32) Trying harder vs. strategic rest 

  • (00:28:05) Morning vs. evening energy dynamics 

  • (00:29:24) The role of strategic breaks 

  • (00:31:27) Focusing on strengths over weaknesses 

  • (00:35:59) Managing negative thoughts and default mode network 

  • (00:43:03) Tools for creating positive thoughts 

  • (00:47:39) Healing trauma and synaptic rewiring 

  • (00:50:58) Gratitude practice and neuroplasticity 

  • (00:55:31) Longevity and healthy aging 

  • (01:01:20) Nicole's perspective on living past 100 



Sponsors: 



Resources: 

Mindsip insights from this episode:

Manage mental currency to boost energy for important tasks

Your brain has a finite bank of energy, or 'mental currency,' and you deplete it on things like mindless scrolling, leaving you irritable and with less energy for important tasks.

Interrupt negative thoughts by generating conscious words

You can interrupt the spontaneous, negative thoughts of your brain's default mode network by consciously generating words and sentences, which engages the frontal cortex.

Maintain endothelial glycocalyx with Arteriosil HP

The endothelial glycocalyx, an ultra-thin lining protecting your 60,000 miles of blood vessels, can be maintained using a product called Arteriosil HP.

Mitigate dopamine neuron decline with a healthy lifestyle

We naturally lose 3% to 10% of our motivation-driving dopaminergic neurons every decade, but this loss can be mitigated by a healthy lifestyle.

Combine niacin, psilocybin, and lion's mane for whole-brain neurogenesis

Emerging research suggests a combination of niacin, psilocybin, and lion's mane mushrooms may cause whole-brain neuron regeneration, not just in the hippocampus.

Pair visualization with physical action to reinforce new habits

For visualization to be effective in creating new habits, it must be paired with the actual physical activity to reinforce the connection between the cerebellum and motor cortex.

Reevaluate chronotypes as labels for circadian rhythm disruption

The popular concept of chronotypes, like being a 'night owl,' might just be a label for different types of circadian rhythm disruption rather than a fixed biological trait.

Prepare for setbacks with a backup plan like Phelps

To build resilience, prepare for setbacks by having a backup plan, just as Michael Phelps trained for his goggles to fill with water before breaking a world record.

Boost mitochondrial performance to enhance willpower and patience

Your willpower and patience are not just a matter of morality but are directly driven by the energy sufficiency of your mitochondria.

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© Mindsip 2025 – Made with ❤ in Vilnius