NAD+: A Quantum Leap in Biohacking – Dr. Gregory Kelly

Dave Asprey

Jan 5, 2024

Episode description

On today’s Upgrade Spotlight episode, we’re talking all about NAD+. In the biohacking world, everyone and their mother has heard of NMN and NAD+, but there’s more to it than meets the eye.

To get into the nitty gritty of NAD+, we’re joined by Dr. Gregory Kelly, a naturopathic physician and the lead product formulator at Neurohacker Collective, also known as Qualia. I’m an advisor to the company, and they do fantastic and innovative work in the longevity space. Their NAD+ supplement is a quantum leap in biohacking and a no-brainer to add to your stack.

In today’s episode, Dr. Kelly explains what NAD is and why it’s essential for longevity, cognition, energy levels, and athletic performance. We talk about the differences between NR, NMN, and Niacinamide. We also explore the most efficient way to get NAD. Is an IV worth the money or will supplements give you more bang for your buck?

Plus, Dr. Kelly breaks down exactly what’s included—and not included—in the Qualia NAD+ formula. I’ve been a major proponent of NAD for more than 10 years, but I don’t like to spend all my time and money getting it. If you feel the same, you’re going to want to tune into this episode.

(00:01:55) What Is NAD & Why Do We Care?

(00:06:19) The Most Efficient Way To Get NAD

(00:09:55) Sirtuin’s Superpowers

(00:14:42) The Qualia NAD+ Formula

(00:22:37) The Buzz on Coffee Berry

(00:25:53) When Is the Best Time To Take NAD+?

(00:30:01) NAD+ in Clinical Trials

(00:34:16) What’s NOT in the Qualia Supplement

(00:38:02) A Quantum Leap for Biohacking

Episode Sponsor

Neurohacker | Boost YOUR NAD+ up to 50%* + GET 50% OFF go to neurohacker.com/DAVENAD.

Resources

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books

Visit neurohacker.com/davenad to save 50% on Qualia NAD+ by Neurohacker

Neurohacker Collective: neurohacker.com

Neurohacker Collective Instagram: @neurohacker

Linkedin: Gregory Kelly

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Mindsip insights from this episode:

Recognize magnesium's role as a key NAD cofactor for energy production

ATP can only function in the body when it's part of an ATP-magnesium complex, making magnesium a crucial cofactor for the energy-dependent pathways that create NAD.

#magnesium

#NAD

Boost NAD levels by 82% with Qualia formula

In a new placebo-controlled study, the Qualia NAD+ formula was shown to increase whole blood NAD levels by an average of 82% over one month.

#NAD

#supplement

Time NAD supplements for optimal metabolic health

Animal studies indicate that taking NAD boosters at the start of your active cycle (morning) improves metabolic health, whereas taking them at the wrong time of day may actually worsen it.

#NAD

#supplement

Combine caffeine and NR to boost NAD levels effectively

Preliminary research suggests caffeine upregulates the final enzyme needed to produce NAD, causing an additive effect when combined with a precursor like NR to raise NAD levels higher than either could alone.

#NAD

#supplement

Utilize fermented B vitamins for enhanced bioactivity

Using B vitamins from a fermented yeast source ensures they are in their coenzyme, food-matrix forms (like P5P for B6), which are more biologically active than standard isolated forms.

#supplement

#vitamin-B

Support ATP production to enhance NAD boosting strategy

A frequently overlooked fact is that ATP is a critical ingredient required to convert NAD precursors into usable NAD, meaning that supporting ATP production is essential for an effective NAD-boosting strategy.

#ATP

#NAD

Streamline NAD metabolome for optimal molecular flow

The NAD metabolome can be viewed as a system of airports, where precursors like NR and NMN are smaller airports feeding into the main NAD+ hub, and the goal is to ensure passengers (molecules) flow through without getting stuck.

#metabolism

#NAD

Choose oral supplements over NAD IVs for effective NAD elevation

Modern, multi-pathway oral supplements may raise intracellular NAD levels more effectively and affordably than expensive and uncomfortable NAD IVs, which struggle to get the large NAD molecule into cells.