People REVERSED their Cancer by eliminating Glycine and Serine - Brilliant Study!
Physionic
Mar 9, 2026
Episode description
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Glycine Restriction Clinical Trial: https://www.youtube.com/watch?v=c74fifu54Sg
0:00 - Introduction
0:40 - Cancer’s Achilles’ Heel
3:08 - Guilty by Association: Glycine
7:27 - Glycine: A Double Agent
9:22 - Everything Considered...
References
*Funding/Conflicts are provides in the free article (found in email list or Physionic Community Article Library)
[Study 561] Tong H, Jiang Z, Song L, et al. Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation. Cell Metab. 2024;36(12):2493-2510. doi:10.1016/j.cmet.2024.10.019
[Study 659] Amelio I, Cutruzzolà F, Antonov A, Agostini M, Melino G. Serine and glycine metabolism in cancer. Trends Biochem Sci. 2014;39(4):191-198. doi:10.1016/j.tibs.2014.02.004.
[Study 660] Labuschagne CF, van den Broek NJF, Mackay GM, et al. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep. 2014;7(4):1248-1258. doi:10.1016/j.celrep.2014.04.045.
[Study 661] Maddocks ODK, Berkers CR, Mason SM, et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature. 2013;493(7433):542-546. doi:10.1038/nature11743.
[Study 662] Maddocks ODK, Athineos D, Cheung EC, et al. Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature. 2017;544(7650):372-376. doi:10.1038/nature22056
[Study 663] Rose ML, Madren J, Bunzendahl H, Thurman RG. Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis. 1999;20(5):793-798. doi:10.1093/carcin/20.5.793.
[Study 664] Maneikyte J, Bausys A, Leber B, et al. Dietary glycine decreases both tumor volume and vascularization in a combined colorectal liver metastasis and chemotherapy model. Int J Biol Sci. 2019;15(8):1582-1590. doi:10.7150/ijbs.35513.
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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.
Mindsip insights from this episode:
Supplement glycine to slow tumor growth
In preclinical studies, supplementing with glycine dramatically slows cancer progression in animal models.
Utilize glycine to disrupt cancer cell DNA production
High levels of glycine can reverse the 'one-carbon metabolism' pathway, making it harder for cancer cells to produce DNA and multiply.
Continue glycine supplementation if cancer-free
If you don't have cancer, there is zero reason to stop supplementing with glycine based on current data.
Restrict serine to inhibit cancer growth
In cell studies, restricting glycine alone does not restrict cancer growth, but restricting serine does.
Implement serine and glycine-free diet to reverse cancer tumors
In a clinical trial, people with advanced cancer saw a mass reversal of their tumors after being put on a serine and glycine-free diet.
Acknowledge incomplete evidence on glycine and serine for cancer recommendations
The evidence is too incomplete for any clinician to offer strong recommendations about glycine or serine for individuals with cancer.
Understand glycine's reversible conversion to serine
The biochemical reaction that converts serine to glycine is reversible, meaning if there's a lot of glycine, it begins being converted back to serine.
