Simple Steps to Boost Your Daily Energy with NAD

Dave Asprey

Jul 19, 2024

Episode description

On this special Upgrade Spotlight episode of The Human Upgrade, you'll explore the science of NAD and its vital role in your cellular health with Dr. Nichola Conlon from Nuchido Laboratories. Learn how NAD supports energy production, cellular repair, and longevity. Dr. Conlon breaks down the latest research on NAD, explaining why levels decline with age and how to naturally boost them without expensive and uncomfortable IV treatments.

Dr. Conlon breaks down innovative ways to enhance your NAD levels, reduce inflammation, and improve overall health and shares practical tips on maintaining high NAD levels through diet, lifestyle changes, and supplementation. You’ll understand how these strategies can combat fatigue, brain fog, and aging symptoms, offering benefits for both physical and cognitive performance.

Tune in to uncover the latest advancements in NAD research and how you can apply them to enhance your cellular health and well-being.

Timestamps:

00:00:00 — 1: Opening

00:01:07 — 2: Introduction to NAD and Dr. Nichola Conlon

00:01:46 — 3: Understanding NAD and Its Functions

00:02:23 — 4: The Challenges of Boosting NAD Levels

00:05:31 — 5: The Science Behind NAD Decline and Aging

00:09:15 — 6: Clinical Studies and Evidence

00:14:35 — 7: Practical Benefits of Boosting NAD

00:19:17 — 8: Addressing Inflammation and Glycation

00:26:32 — 10: Big Pharma vs. Supplement Approach

00:30:10 — 11: Enhancing Bioavailability of Supplements

00:33:45 — 12: Impact on Chronic Conditions

00:37:05 — 13: Addressing Autoimmunity and Inflammation

00:44:00 — 15: Final Thoughts and Recommendations

Sponsors:

Nuchido | Go to Nuchido.com/Upgrade, or use code Upgrade10, for a 10% discount!

Resources:

Nuchido.com/Upgrade, or use code Upgrade10, for a 10% discount!
Follow Nuchido on Instagram: @Nuchido
Nuchido’s Linktree: https://linkin.bio/nuchido/
Dave's Linktree: https://linktr.ee/daveasprey
Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
Follow Dave on Instagram: @Dave.Asprey
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Mindsip insights from this episode:

Reverse biological age and reduce glycation in 28 days with Nucito

A clinical study on the Nucito supplement showed a reversal of biological age by 1.26 years and a reduction in glycation within 28 days.

#biological-age

#supplement

Restore NAD to alleviate menopausal brain fog

One of the top reported benefits of restoring NAD is a significant improvement in brain fog, especially for menopausal and perimenopausal women.

#menopause

#NAD

Avoid NMN to prevent inflammation from CD38 activation

Some studies show that taking the precursor NMN by itself can actually drive inflammation by fueling the NAD-consuming enzyme CD38.

#inflammation

#supplement

Combat chronic inflammation to preserve NAD levels

Chronic inflammation causes an increase in an enzyme called CD38, which is one of the most prolific consumers of NAD in the body.

#inflammation

#NAD

Understand why NAD precursors may stop working with age

Taking NAD precursors like NMN may stop working because the key enzyme (NAMPT) that converts them into NAD declines with age.

#aging

#NAD

Address elevated CD38 to combat chronic fatigue post-viral infection

Chronic fatigue following a viral infection is linked to elevated CD38, which depletes mitochondrial energy by consuming available NAD.

#fatigue

#mitochondria

Limit CD38 activity to preserve NAD levels

The inflammatory enzyme CD38 consumes 100 molecules of NAD for every one cycle it performs, while beneficial sirtuin enzymes only use about seven.

#enzyme

#NAD

Utilize natural extracts for enhanced bioavailability

Using natural plant extracts like Sophora Japonica for rutin can be more effective than pure molecules like quercetin due to superior bioavailability.