David Sinclair is accused of using the same strategy with NMN as he did with resveratrol: hyping it, creating a proprietary version, and lobbying to ban competitors.

Initial studies claiming resveratrol extended lifespan in worms and flies could not be replicated and were found to have no effect when performed correctly.

The belief that resveratrol activates the SIRT1 enzyme was based on a lab error, where a fluorescent dye mixed with the resveratrol was actually causing the effect.

Resveratrol didn't extend lifespan in mice; it only prevented death in mice fed a toxic diet that caused their livers to enlarge and crush their lungs.

The Interventions Testing Program, a rigorous government-funded study, found that even high doses of resveratrol, recommended by David Sinclair, had no effect on mouse longevity.

Contrary to popular claims, poor absorption is not why resveratrol trials failed, as modern supplements and studies use a well-absorbed micronized form.

Multiple studies show that taking micronized resveratrol supplements can blunt the positive effects of exercise and lower testosterone levels.

Prominent researchers, including Matt Kaeberlein and a former Harvard Medical School Dean, have publicly accused David Sinclair of being a 'snake oil salesman' for his claims.