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0:00 - Introduction
1:26 - Cochrane Analysis Background - Were we Wrong?
4:08 - Biases in Blood Pressure Studies
6:51 - Relative vs Absolute Risk - Knowing the Difference
10:48 - Risks with Lower Blood Pressure
16:41 - Were we all wrong?
26:45 - Main Points
Dr. Boz's Video: https://www.youtube.com/live/iddnc_tR-T0?si=MLZNlzDxaNk5Qxpz
References
[Study 413] SPRINT Research Group, Wright JT Jr, Williamson JD, et al. A Randomized Trial of Intensive versus Standard Blood-Pressure Control [published correction appears in N Engl J Med. 2017 Dec 21;377(25):2506. doi: 10.1056/NEJMx170008.]. N Engl J Med. 2015;373(22):2103-2116. doi:10.1056/NEJMoa1511939
Funding/Conflicts: Public Funding [National Institutes of Health (NIH); Clinical and Translational Science Awards; Department of Veterans Affairs] // Potential Conflicts of Interest [Drugs were donated by Takeda and Arbor Pharmaceutical]
[Study 437] Saiz LC, Gorricho J, Garjón J, Celaya MC, Erviti J, Leache L. Blood pressure targets for the treatment of people with hypertension and cardiovascular disease. Cochrane Database Syst Rev. 2022;11(11):CD010315. Published 2022 Nov 18. doi:10.1002/14651858.CD010315.pub5
Funding/Conflicts: Public Funding [This project was supported by the [Cochrane Hypertension Group] through infrastructure funding from the [National Institute for Health Research (NIHR)] // No direct Conflicts of Interest
[C] ACCORD Study Group, Cushman WC, Evans GW, et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1575-1585. doi:10.1056/NEJMoa1001286
[D] Yang Q, Zheng R, Wang S, et al. Systolic Blood Pressure Control Targets to Prevent Major Cardiovascular Events and Death in Patients With Type 2 Diabetes: A Systematic Review and Network Meta-Analysis. Hypertension. 2023;80(8):1640-1653. doi:10.1161/HYPERTENSIONAHA.123.20954
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