The Heart Disease Protein you've Never Heard

Physionic

Sep 4, 2025

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:35 - MPO - A Risk
4:12 - How do we reduce MPO?
6:58 - Main Points

Reference
[Study 514] Hof A, Landerer M, Peitsmeyer P, et al. Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity. Cell Rep Med. 2025;6:102087. doi:10.1016/j.xcrm.2025.102087

Funding/Conflicts: Mixed Funding [Public: Deutsche Forschungsgemeinschaft (DFG)—GRK 2407 [360043781] to M.M., H.W., D.M., S.G.; SFB TRR259 [397484323] project A04 to H.W. and S. Baldus, project B05 to M. Adam, project A08 to A.P. and S.H., project C03 to M.M.; MO 3438/2-1 to M.M.; HO 5279/2-1 to F.F.H.; Center for Molecular Medicine Cologne (CMMC) B12 to H.W. and M.M.; Koeln Fortune Program (344/2019 to S. Braumann, 363/2020 to F.S.N., 248/2021 to A.H.); Non-Profit Funding: Neven-DuMont Foundation to H.W.] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cardiovascularhealth #heartdiseaseawereness

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:35 - MPO - A Risk
4:12 - How do we reduce MPO?
6:58 - Main Points

Reference
[Study 514] Hof A, Landerer M, Peitsmeyer P, et al. Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity. Cell Rep Med. 2025;6:102087. doi:10.1016/j.xcrm.2025.102087

Funding/Conflicts: Mixed Funding [Public: Deutsche Forschungsgemeinschaft (DFG)—GRK 2407 [360043781] to M.M., H.W., D.M., S.G.; SFB TRR259 [397484323] project A04 to H.W. and S. Baldus, project B05 to M. Adam, project A08 to A.P. and S.H., project C03 to M.M.; MO 3438/2-1 to M.M.; HO 5279/2-1 to F.F.H.; Center for Molecular Medicine Cologne (CMMC) B12 to H.W. and M.M.; Koeln Fortune Program (344/2019 to S. Braumann, 363/2020 to F.S.N., 248/2021 to A.H.); Non-Profit Funding: Neven-DuMont Foundation to H.W.] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cardiovascularhealth #heartdiseaseawereness

Mindsip insights from this episode:

Reduce cardiovascular risk by losing weight to lower MPO levels

Data from bariatric surgery patients shows that they experience significant drops in MPO levels, suggesting weight loss is a key strategy for reducing this cardiovascular risk factor.

Test myeloperoxidase to assess arterial health

Myeloperoxidase (MPO) is a specific inflammatory marker for arterial health that you can measure through a publicly available blood test.

Reduce myeloperoxidase levels to improve artery function

The enzyme myeloperoxidase (MPO) directly attacks and stiffens your arteries, with higher blood levels of MPO being associated with reduced blood vessel function.

Combat artery damage by managing fat cell health

Fat cells surrounding your blood vessels can release molecules that attract immune cells, which in turn release the damaging MPO enzyme.

Reduce MPO enzyme to enhance adiponectin levels and combat inflammation

The MPO enzyme reprograms fat cells to release less of the beneficial hormone adiponectin, which further contributes to artery stiffening and inflammation.

Manage visceral fat to control MPO levels

Your fat mass, and specifically your visceral fat, is a major determinant of your MPO levels because this inflammatory process originates in the fat tissue.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius