The Most Incredible Fasting Study I’ve Ever Read

Physionic

Oct 27, 2025

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

Fasting increases Inflammation: https://youtu.be/Sj-SezJXrqA?si=vZh8fHNJDP-2110e
Fasting and Autophagy in Immune Cells: https://youtu.be/PfsIfpt0E3g?si=CsaA0GC-baEP1uL3

0:00 - Introduction
0:28 - Incredible Fasting
8:07 - Main Points/Take Aways

Reference
[Study 534] Naveen Kumar GV, Wang R-S, Sharma AX, et al. Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting. Nat Commun. 2025;16:1330. doi:10.1038/s41467-025-56613-3

Funding/Conflicts: Public Funding: This work was supported by the National Institutes of Health: KL2 TR002542 (to P.K.F.); R01 DK137913 (to M.L.S.); no other public grants are listed.; Non-Profit Funding: No non-profit funders are listed; no non-profit grants are disclosed in the acknowledgements.; Industry Funding / Conflicts: The authors report no industry funding for this study; outside the submitted work, P.K.F. reports consulting for Regeneron; advisory board service for Camurus, Crinetics, and Amryt/Chiesi; and research funding from Crinetics, Corcept, and Quest; all other authors declare no competing interests.

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#fasting #fastingforhealth #fastingscience

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

Fasting increases Inflammation: https://youtu.be/Sj-SezJXrqA?si=vZh8fHNJDP-2110e
Fasting and Autophagy in Immune Cells: https://youtu.be/PfsIfpt0E3g?si=CsaA0GC-baEP1uL3

0:00 - Introduction
0:28 - Incredible Fasting
8:07 - Main Points/Take Aways

Reference
[Study 534] Naveen Kumar GV, Wang R-S, Sharma AX, et al. Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting. Nat Commun. 2025;16:1330. doi:10.1038/s41467-025-56613-3

Funding/Conflicts: Public Funding: This work was supported by the National Institutes of Health: KL2 TR002542 (to P.K.F.); R01 DK137913 (to M.L.S.); no other public grants are listed.; Non-Profit Funding: No non-profit funders are listed; no non-profit grants are disclosed in the acknowledgements.; Industry Funding / Conflicts: The authors report no industry funding for this study; outside the submitted work, P.K.F. reports consulting for Regeneron; advisory board service for Camurus, Crinetics, and Amryt/Chiesi; and research funding from Crinetics, Corcept, and Quest; all other authors declare no competing interests.

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#fasting #fastingforhealth #fastingscience

Mindsip insights from this episode:

Elevate autophagy through 10-day fasting for fat loss

In humans fasting for 10 days, genes related to autophagy were elevated in fat tissue, suggesting this mechanism also applies to people.

Explore immune cell crosstalk with fat during fasting

During fasting, there is a fascinating crosstalk where immune cells invade fat tissue to take up fat vesicles, potentially using their own autophagy process.

Utilize autophagy during fasting to meet fat release demands

The body may switch to autophagy during a fast because the normal lipolysis system is too slow to meet the high demand for fat release.

Activate autophagy for effective fat loss through fasting

Fasting activates a 'non-canonical' fat loss mechanism through autophagy, rather than elevating the enzymes for the typical process of lipolysis.

Understand lipophagy for effective fat breakdown

The more accurate scientific term for the process of fat cells using autophagy to break down fat is 'lipophagy'.

Shift to autophagy for enhanced fat breakdown during fasting

As a fast progresses, the body performs a 'metabolism handoff,' shifting from traditional lipolysis to the more powerful autophagy system for fat breakdown.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius