
The Most Incredible Fasting Study I’ve Ever Read
Physionic
Oct 27, 2025
Mindsip insights from this episode:
Elevate autophagy through 10-day fasting for fat loss
In humans fasting for 10 days, genes related to autophagy were elevated in fat tissue, suggesting this mechanism also applies to people.
Explore immune cell crosstalk with fat during fasting
During fasting, there is a fascinating crosstalk where immune cells invade fat tissue to take up fat vesicles, potentially using their own autophagy process.
Utilize autophagy during fasting to meet fat release demands
The body may switch to autophagy during a fast because the normal lipolysis system is too slow to meet the high demand for fat release.
Activate autophagy for effective fat loss through fasting
Fasting activates a 'non-canonical' fat loss mechanism through autophagy, rather than elevating the enzymes for the typical process of lipolysis.
Understand lipophagy for effective fat breakdown
The more accurate scientific term for the process of fat cells using autophagy to break down fat is 'lipophagy'.
Shift to autophagy for enhanced fat breakdown during fasting
As a fast progresses, the body performs a 'metabolism handoff,' shifting from traditional lipolysis to the more powerful autophagy system for fat breakdown.
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