
This Machine Made Me Younger (Insane Results)
Bryan Johnson
May 29, 2025
Mindsip insights from this episode:
Reverse a decade of aging with telomere therapy
The therapy increased telomere length by 300 base pairs, which is roughly equivalent to reversing a decade of age-related telomere loss.
Eliminate systemic inflammation with hyperbaric oxygen therapy
After 60 sessions of hyperbaric oxygen therapy, high-sensitivity CRP, a marker for systemic inflammation, became undetectable in the body.
Utilize electronics in HBOT chamber for productivity
You can safely use electronics inside the chamber to work, as the ambient air remains at 21% oxygen, making the time commitment more manageable.
Implement 20 HBOT sessions every three months for optimal maintenance
Experts currently suggest a maintenance protocol of 20 sessions every three months to sustain the benefits of HBOT.
Implement oxygen cycling protocol for therapeutic benefits
The protocol involves alternating between 20 minutes of breathing 100% oxygen and a five-minute break on ambient air to create a therapeutic high-to-low oxygen fluctuation.
Reduce Alzheimer's marker P-Tau127 by 28% with 90-day protocol
A specific marker for Alzheimer's disease, P-Tau127, declined by 28.6% following the 90-day protocol.
Boost blood vessel growth with 300% increase in VEGF therapy
The therapy prompted a 300% increase in VEGF, a signal that boosts the growth of new blood vessels throughout the body.
Enhance supplement absorption with HBOT and Akkermansia boost
The gut bacteria Akkermansia, which was undetectable even with supplementation, increased by 1000% after combining the supplement with HBOT.
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