Vitamin D: Bone Healer or Bone Breaker? Both, in fact.

Physionic

Jan 27, 2025

Episode description

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0:00 - Introduction
0:22 - Vitamin D: Destroying Bone? Building Bone?
5:52 - Vitamin D on Bone Density - Mystery thickens...
10:10 - 5 Factors for Effectiveness
11:13 - The Biphasic Response of Vitamin D
12:29 - Main Points

[Study 332] Li, Y., Zhao, P., Jiang, B. et al. Modulation of the vitamin D/vitamin D receptor system in osteoporosis pathogenesis: insights and therapeutic approaches. J Orthop Surg Res 18, 860 (2023). https://doi.org/10.1186/s13018-023-04320-4

Public Funding - High-end Foreign Expert Program of the Ministry of Science, China // No Conflicts of Interest

[Study 333] Nakamichi Y, Udagawa N, Suda T, Takahashi N. Mechanisms involved in bone resorption regulated by vitamin D. J Steroid Biochem Mol Biol. 2018;177:70-76. doi:10.1016/j.jsbmb.2017.11.005

Public Funding - Japan Society of the Promotion of Science // No Conflicts of Interest

[Study 330] Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014;383(9912):146-155. doi:10.1016/S0140-6736(13)61647-5

Funding/Conflicts: Public Funding - Health Research Council of New Zealand // No Conflicts of Interest

[Study 329] Kazemian E, Pourali A, Sedaghat F, et al. Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis. Nutr Rev. 2023;81(5):511-530. doi:10.1093/nutrit/nuac068

Internal Funding: Alborz University of Medical Sciences // Conflict of Interest: One researcher is a consultant for Pharmaceutical

[Study 331] Yao P, Bennett D, Mafham M, et al. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(12):e1917789. Published 2019 Dec 2. doi:10.1001/jamanetworkopen.2019.17789

Public Funding: Sin-British Fellowship Trust scholarship / One of the researchers is funded by the non-profit UK Medical Research Council

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#vitamind #bonehealth #bonehealthtips

Episode description

THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:22 - Vitamin D: Destroying Bone? Building Bone?
5:52 - Vitamin D on Bone Density - Mystery thickens...
10:10 - 5 Factors for Effectiveness
11:13 - The Biphasic Response of Vitamin D
12:29 - Main Points

[Study 332] Li, Y., Zhao, P., Jiang, B. et al. Modulation of the vitamin D/vitamin D receptor system in osteoporosis pathogenesis: insights and therapeutic approaches. J Orthop Surg Res 18, 860 (2023). https://doi.org/10.1186/s13018-023-04320-4

Public Funding - High-end Foreign Expert Program of the Ministry of Science, China // No Conflicts of Interest

[Study 333] Nakamichi Y, Udagawa N, Suda T, Takahashi N. Mechanisms involved in bone resorption regulated by vitamin D. J Steroid Biochem Mol Biol. 2018;177:70-76. doi:10.1016/j.jsbmb.2017.11.005

Public Funding - Japan Society of the Promotion of Science // No Conflicts of Interest

[Study 330] Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014;383(9912):146-155. doi:10.1016/S0140-6736(13)61647-5

Funding/Conflicts: Public Funding - Health Research Council of New Zealand // No Conflicts of Interest

[Study 329] Kazemian E, Pourali A, Sedaghat F, et al. Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis. Nutr Rev. 2023;81(5):511-530. doi:10.1093/nutrit/nuac068

Internal Funding: Alborz University of Medical Sciences // Conflict of Interest: One researcher is a consultant for Pharmaceutical

[Study 331] Yao P, Bennett D, Mafham M, et al. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(12):e1917789. Published 2019 Dec 2. doi:10.1001/jamanetworkopen.2019.17789

Public Funding: Sin-British Fellowship Trust scholarship / One of the researchers is funded by the non-profit UK Medical Research Council

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#vitamind #bonehealth #bonehealthtips

Mindsip insights from this episode:

Understand vitamin D's dual role in bone health

The vitamin D receptor can both increase bone production and decrease it by using the exact same mechanism involving RANK L and OPG proteins.

Utilize modest doses of vitamin D3 for optimal bone health

Most studies indicating effectiveness for bone health used modest doses between 400 and 800 IU of vitamin D3.

Skip vitamin D supplementation if levels are normal and under 65

If your blood vitamin D levels are normal and you are under 65, supplementing with vitamin D for bone health is probably not necessary.

Target vitamin D supplementation for those most in need

Supplementation is most effective for people who are deficient, women, and individuals over the age of 65.

Avoid high-dose vitamin D shots to protect bone health

Large, single-dose vitamin D shots of 100,000 IUs or more can have unintended bone-weakening effects due to its paradoxical impact on bone cells.

Maintain optimal vitamin D levels to protect bone health

Researchers propose a biphasic response where both too low and very high vitamin D levels lead to greater bone breakdown, while normal levels are optimal.

Evaluate conflicting studies on vitamin D supplementation for bone health

Two large meta-analyses on vitamin D supplementation for bone health show contradictory results, with one indicating no effect and the other showing a clear benefit.

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