
Vitamin D: Bone Healer or Bone Breaker? Both, in fact.
Physionic
Jan 27, 2025
Mindsip insights from this episode:
Understand vitamin D's dual role in bone health
The vitamin D receptor can both increase bone production and decrease it by using the exact same mechanism involving RANK L and OPG proteins.
Utilize modest doses of vitamin D3 for optimal bone health
Most studies indicating effectiveness for bone health used modest doses between 400 and 800 IU of vitamin D3.
Skip vitamin D supplementation if levels are normal and under 65
If your blood vitamin D levels are normal and you are under 65, supplementing with vitamin D for bone health is probably not necessary.
Target vitamin D supplementation for those most in need
Supplementation is most effective for people who are deficient, women, and individuals over the age of 65.
Avoid high-dose vitamin D shots to protect bone health
Large, single-dose vitamin D shots of 100,000 IUs or more can have unintended bone-weakening effects due to its paradoxical impact on bone cells.
Maintain optimal vitamin D levels to protect bone health
Researchers propose a biphasic response where both too low and very high vitamin D levels lead to greater bone breakdown, while normal levels are optimal.
Evaluate conflicting studies on vitamin D supplementation for bone health
Two large meta-analyses on vitamin D supplementation for bone health show contradictory results, with one indicating no effect and the other showing a clear benefit.
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