Where a Mediterranean Diet Fails, another Diet Succeeds: Psoriatic Arthritis

Physionic

May 16, 2025

Episode description

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0:00 - Introduction
0:33 - Psoriasis and Psoriatic Arthritis Mechanisms
2:14 - The Study
2:52 - What happened?
5:34 - How this works...
6:50 - Does it work through these mechanisms?
7:18 - Important details on the Diet
8:05 - An additional consideration...
8:22 - Main Points

Reference
[Study 448] Lambadiari V, Katsimbri P, Kountouri A, et al. The Effect of a Ketogenic Diet versus Mediterranean Diet on Clinical and Biochemical Markers of Inflammation in Patients with Obesity and Psoriatic Arthritis: A Randomized Crossover Trial. Int J Mol Sci. 2024;25(5):2475. Published 2024 Feb 20. doi:10.3390/ijms25052475

Funding/Conflicts: No External Funding / Potential direct Conflicts of Interest [Two of the study authors disclosed professional affiliations with Evivios Med: D.V. is the General Director, and S.M. is a dietician with the organization]

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Episode description

Mindsip insights from this episode:

Inhibit inflammasome with ketones to reduce arthritis

The ketone beta-hydroxybutyrate, produced on a ketogenic diet, may reduce arthritis by inhibiting a cellular protein complex called the inflammasome.

#arthritis

#metabolism

Achieve 50% reduction in arthritis symptoms with ketogenic diet

The ketogenic diet led to a massive 50% reduction in arthritis symptoms, which is a tremendously large effect size for a dietary intervention.

#arthritis

#keto

Implement ketogenic diet to lower inflammatory markers

The ketogenic diet significantly reduced inflammatory molecules like Interleukin 6 and Interleukin 17, while the Mediterranean diet failed to do so.

#inflammation

#keto

Embrace unsaturated-fat keto diet for better health

The ketogenic diet in the study was not a typical high-saturated-fat version, as it encouraged unsaturated fats from sources like olive oil.

#keto

#olive-oil

Focus on diet components for arthritis benefits, not just weight loss

Because weight loss was similar between the keto and Mediterranean diet groups, the arthritis benefits were due to the diet's components, not just weight reduction.

#arthritis

#nutrition

Choose ketogenic diet to alleviate psoriatic arthritis symptoms

A ketogenic diet was found to be superior to a Mediterranean diet for massively reducing psoriatic arthritis symptoms and inflammation.

#arthritis

#keto

Reevaluate Mediterranean diet's effectiveness for arthritis management

In a randomized controlled trial comparing diets for psoriatic arthritis, the Mediterranean diet provided no statistically significant benefit for symptoms.