Where a Mediterranean Diet Fails, another Diet Succeeds: Psoriatic Arthritis
Physionic
May 16, 2025
Episode description
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0:00 - Introduction
0:33 - Psoriasis and Psoriatic Arthritis Mechanisms
2:14 - The Study
2:52 - What happened?
5:34 - How this works...
6:50 - Does it work through these mechanisms?
7:18 - Important details on the Diet
8:05 - An additional consideration...
8:22 - Main Points
Reference
[Study 448] Lambadiari V, Katsimbri P, Kountouri A, et al. The Effect of a Ketogenic Diet versus Mediterranean Diet on Clinical and Biochemical Markers of Inflammation in Patients with Obesity and Psoriatic Arthritis: A Randomized Crossover Trial. Int J Mol Sci. 2024;25(5):2475. Published 2024 Feb 20. doi:10.3390/ijms25052475
Funding/Conflicts: No External Funding / Potential direct Conflicts of Interest [Two of the study authors disclosed professional affiliations with Evivios Med: D.V. is the General Director, and S.M. is a dietician with the organization]
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Mindsip insights from this episode:
Inhibit inflammasome with ketones to reduce arthritis
The ketone beta-hydroxybutyrate, produced on a ketogenic diet, may reduce arthritis by inhibiting a cellular protein complex called the inflammasome.
Achieve 50% reduction in arthritis symptoms with ketogenic diet
The ketogenic diet led to a massive 50% reduction in arthritis symptoms, which is a tremendously large effect size for a dietary intervention.
Implement ketogenic diet to lower inflammatory markers
The ketogenic diet significantly reduced inflammatory molecules like Interleukin 6 and Interleukin 17, while the Mediterranean diet failed to do so.
Embrace unsaturated-fat keto diet for better health
The ketogenic diet in the study was not a typical high-saturated-fat version, as it encouraged unsaturated fats from sources like olive oil.
Focus on diet components for arthritis benefits, not just weight loss
Because weight loss was similar between the keto and Mediterranean diet groups, the arthritis benefits were due to the diet's components, not just weight reduction.
Choose ketogenic diet to alleviate psoriatic arthritis symptoms
A ketogenic diet was found to be superior to a Mediterranean diet for massively reducing psoriatic arthritis symptoms and inflammation.
Reevaluate Mediterranean diet's effectiveness for arthritis management
In a randomized controlled trial comparing diets for psoriatic arthritis, the Mediterranean diet provided no statistically significant benefit for symptoms.
