Why You’re Still Tired — And How to Fix It (with Dr. Andy Galpin)

Mark Hyman

Jun 18, 2025

Episode description

On this episode of The Dr. Hyman Show, Dr. Galpin, a leading expert in human performance, shares how to use your blood work, sleep metrics, and movement data in a way that actually helps you feel better—not just check more boxes.

We discuss: 

• What most people get wrong about sleep—and how to fix it

• Why early testing can change your long-term health

• How muscle impacts your brain, hormones, and aging

• What high performers do differently—and how to apply it to your life

Whether you want more energy, better sleep, or a smarter way to track your health—this one’s a game changer. 

Tune in—you don’t want to miss it.

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Mindsip insights from this episode:

Recognize afternoon fatigue as a normal physiological response

Feeling a bit tired in the afternoon is a normal physiological response and should not automatically be pathologized as a disorder or deficiency.

Monitor sodium-to-potassium ratio to identify overtraining stress

A low sodium-to-potassium ratio in blood work can indicate high allostatic load from overtraining, signaling a need for rest rather than a dietary change.

Build high-quality muscle to prevent metabolic problems

It is extraordinarily rare to have type 2 diabetes if you have high-quality muscle mass, making it a key defense against metabolic issues.

Build resilience to thrive through life's challenges

The goal isn't to be anti-aging by minimizing all risk, but to be anti-fragile by building the resilience to handle life's insults and enjoy experiences.

Avoid obsession with sleep trackers to prevent orthosomnia

Obsessing over data from consumer sleep trackers can induce a clinical sleep disorder known as orthosomnia.

Establish consistent wind-down routine to signal sleep

The key to a successful wind-down routine is the consistent pattern of activities, which acts as a Pavlovian cue to signal your body it's time for sleep.

Aim for resilient sleep over optimal sleep

Instead of striving to be an optimal sleeper, it's more beneficial to be a resilient sleeper who can perform well even with inconsistent schedules.

Prioritize sleep regularity over total hours for better energy

For your perceived energy levels, sleep regularity will have a bigger impact than the total number of hours you sleep.

Train your brain for toughness through discomfort

Pushing through discomfort develops specific areas of the brain, meaning toughness is a learnable skill that can be physically built.

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