You Have A 25% Chance to Lose All Your Memory (Longevity Secrets)

Dave Asprey

Aug 26, 2025

Episode description

Alzheimer’s is not inevitable—and it may even be optional. In this groundbreaking episode, you’ll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer’s researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer’s is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance.

Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You’ll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life.

This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You’ll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee.

You’ll Learn:

• Why Alzheimer’s can begin as early as your 20s and what biomarkers to track

• The seven major drivers of Alzheimer’s and how to reverse them with biohacking strategies

• How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it

• The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity

• Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s

• How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are rele

Episode description

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

You’ll Learn:

• Why Alzheimer’s can begin as early as your 20s and what biomarkers to track

• The seven major drivers of Alzheimer’s and how to reverse them with biohacking strategies

• How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it

• The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity

• Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s

• How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity

Episodes are rele

Mindsip insights from this episode:

Recognize prions as antimicrobial agents in brain defense

Prions, typically known as infectious agents, are also antimicrobial and are produced by the brain as a defense mechanism against infection.

#bacteria

Focus on incremental changes to improve brain health

Since Alzheimer's is never caused by a single factor, you don't have to fix every problem at once, just enough of them to shift your brain's network back toward health.

#Alzheimer's

#brain

Utilize nattokinase to break micro-clots for brain health post-COVID

The supplement nattokinase is very helpful for breaking up the micro-clots created by COVID, which can negatively impact brain and heart health.

#COVID-19

#supplement

Utilize mitochondrial transfusions to combat Parkinson's disease

Mitochondrial transfusions are considered one of the most promising future therapies for Parkinson's disease because they directly address its root cause in mitochondrial dysfunction.

#mitochondria

#Parkinson's

Reduce exposure to organic toxins to mitigate Parkinson's risk

The recent increase in Parkinson's disease is strongly linked to exposure to specific organic toxins like TCE and PCE, which are found in degreasing agents.

#Parkinson's

#toxin

Detect Alzheimer's risk in your 20s for early intervention

The biochemical path that leads to an Alzheimer's diagnosis can be detected in people as young as their 20s, decades before symptoms appear.

#Alzheimer's

#risk

Shift brain from protection to connection mode for growth

Your brain operates in either a 'connection mode' for growth or a 'protection mode' when under threat, and Alzheimer's is a chronic state of this protective downsizing.

#Alzheimer's

#cognition

Avoid standard Alzheimer's drugs if carrying APOE4 gene

For patients with two copies of the APOE4 gene, standard antibody-based Alzheimer's drugs can actually accelerate cognitive decline instead of slowing it.

#Alzheimer's

#APOE4

Reframe amyloid and tau as protective agents against brain insults

The amyloid and tau proteins, often seen as the cause of Alzheimer's, are actually part of the brain's protective, antimicrobial response to insults like toxins and pathogens.

#Alzheimer's

#brain

Prevent Alzheimer's by understanding early stages and root causes

With a modern understanding of its early stages and root causes, getting Alzheimer's disease is now considered optional if you start prevention early.