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0:00 - Introduction
0:30 - Hacking Fasting's Longevity Signatures
4:20 - Main Points
References
[Study 533] Hu F, Yu L, Tu X, et al. A high-fiber diet mimics aging-related signatures of caloric restriction in mammals. Nat Commun. 2025;16(1):5917. doi:10.1038/s41467-025-61046-z
Funding/Conflicts: Mixed Funding [Public Funding: This work was supported by public grants from the National Natural Science Foundation of China, the National Key R&D Program of China, the Shanghai Jiao Tong University Medical Engineering Cross Research Fund, startup funding from Shanghai Jiao Tong University, and the China Postdoctoral Science Foundation; Non-Profit Funding: No non-profit funding sources were mentioned in the article; Industry Funding: No industry funding sources were mentioned in the article] // Conflicts of Interest: The authors declared no competing interests.
[A] Di Francesco A, Deighan AG, Litichevskiy L, et al. Dietary restriction impacts health and lifespan of genetically diverse mice. Nature. 2024;634(8034):684-692. doi:10.1038/s41586-024-08026-3
[B] Colman RJ, Anderson RM, Johnson SC, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;325(5937):201-204. doi:10.1126/science.1173635
[C] Ramezani F, Pourghazi F, Eslami M, et al. Dietary fiber intake and all-cause and cause-specific mortality: An updated systematic review and meta-analysis of prospective cohort studies. Clin Nutr. 2024;43(1):65-83. doi:10.1016/j.clnu.2023.11.005
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