ONE Tiny Blood Spot = HUNDREDS (!) Of Biomarkers, Age & Disease Prediction With Dr. Matt Dawson

Ben Greenfield

Apr 23, 2026

Episode description

Full Show Notes: https://bengreenfieldlife.com/trupodcast

In this episode with repeat guest Dr. Matt Dawson, you’ll discover how epigenetic testing analyzes DNA methylation to reveal how fast you’re biologically aging, what’s driving your health, and your risk for disease. You’ll explore how these signals can detect chronic disease risk earlier than traditional labs, and how TruDiagnostic built the TruHealth Test by analyzing ~1,000 biomarkers to pinpoint the most meaningful health indicators. We also break down the TruAge Test, covering biological age, pace of aging, and organ-specific aging, plus insights from my own results. We discuss how AI and large language models (LLMs) identify which interventions actually improve specific biomarkers, and what truly moves the needle for longevity, from caloric restriction and GLP-1 drugs to the often-overlooked impact of relationships, stress, and recovery.

👉 Receive 20% off your TruAge + TruHealth kit with code BEN20 here.

Dr. Matt Dawson is a physician-entrepreneur focused on genomics and epigenetics. He has founded six companies, authored two medical textbooks, contributed to over two dozen scientific publications, and lectured in more than 20 countries. As founder of Wild Health, he built a nationwide genomics-based precision medicine practice later acquired by a publicly traded tech company. He now serves as CEO of TruDiagnostic, an epigenetic longevity laboratory leveraging AI and biomarkers to transform chronic disease diagnosis.

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Mindsip insights from this episode:

Ensure biological age test meets four essential criteria

A good biological age test must be published, predict outcomes better than chronological age, be reliable (high ICC), and respond to interventions.

#biological-age

#testing

Activate neuroplasticity genes with ayahuasca

Preliminary, unpublished data from a study on ayahuasca showed it turned on genes related to neuroplasticity, including those that express BDNF.

#neuroplasticity

#psychedelics

Utilize key biological age tests to assess mortality risk and aging speed

The most reliable biological age tests measure your overall mortality risk (Omyc age), your current speed of aging (Dunedin PACE), and the aging of individual organ systems (Symphony Age).

#biological-age

#mortality

Increase ketone levels to potentially slow aging

Anecdotal evidence suggests that increasing ketone levels through exogenous ketones, even without dietary changes, can have an interesting and positive effect on the pace of aging.

#aging

#supplement

Allow 48-72 hours of rest before epigenetic testing

An intense workout or a long flight the day before testing can acutely affect your epigenetic markers, so it's best to test after a 48-72 hour washout period of rest.

#epigenetics

#testing

Build AI coach for personalized training and supplement plans

An AI coach can be built by feeding it your health data, biometrics, and fitness goals to generate a complete, adaptive training and supplement plan.

#AI

#training

Utilize Dunedin PACE test to predict aging outcomes

The brand new BASE II trial found that the Dunedin PACE test is the single strongest predictor of morbidity and mortality, even surpassing metrics like VO2 max and grip strength.

#aging

#mortality

Prioritize relationships over biohacks for longevity

According to a definitive 80-year Harvard study, the quality of your social relationships is a stronger predictor of longevity than smoking status or any other biohack.

#longevity

#relationships

Utilize epigenetic biomarkers for superior disease prediction

Epigenetic predictions of biomarkers like CRP or Hemoglobin A1C can be more predictive of disease outcomes than the direct measurements from a traditional lab test.

#diagnosis

#epigenetics

Leverage lifestyle choices to influence epigenetics for better health outcomes

While your DNA accounts for about 20% of your health outcome, epigenetics measures the other 80% which is influenced by your lifestyle choices like diet, sleep, and stress.

#epigenetics

#health

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