
A Protein is Protecting You from Chronic Disease—And You’re Shutting It Off Eating THIS Way!
Physionic
Aug 14, 2025
Mindsip insights from this episode:
Understand visceral fat's role in inflammation through WNT10 signaling
Visceral fat tissue communicates with immune cells by releasing a protein called WNT10, which in turn controls beta-catenin levels and inflammation.
Avoid Western diet to enhance anti-inflammatory signals
A Western diet, rich in sugar and saturated fats, reduces WNT10 release from visceral fat, which lowers beta-catenin and increases inflammation.
Activate Frizzled and Disheveled to combat inflammation
The pathway that protects beta-catenin involves proteins with humorous names, where a signal binds to a receptor called "Frizzled," which then activates a protein called "Disheveled.".
Leverage beta-catenin to regulate inflammation
A protein called beta-catenin, while not common in clinical discussions, plays a powerful role in keeping inflammation throughout your body in check.
Investigate human links between beta-catenin, WNT, and visceral fat inflammation
While the mechanism is shown in animal studies, there is currently little good research directly linking beta-catenin and WNT from visceral fat to inflammation in humans.
Recognize immune cells in visceral fat to manage inflammation
Your visceral fat tissue contains immune cells, specifically a subpopulation called dendritic cells that can activate a pro-inflammatory response.
Activate beta-catenin to reduce inflammation in dendritic cells
Activating beta-catenin in dendritic cells dramatically reduces the release of pro-inflammatory molecules like Interleukin 6 (IL-6).
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