A Protein is Protecting You from Chronic Disease—And You’re Shutting It Off Eating THIS Way!

Physionic

Aug 14, 2025

Episode description

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*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

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Created with Biorender

0:00 - Introduction
1:20 - Dendritic Cells & Inflammation
4:05 - Visceral Fat, Beta-Catenin, and your Health
6:52 - Visceral Fat reduces Inflammation??
9:15 - How do we preserve Beta-Catenin?
11:18 - Main Points

References
[Study 506] Macdougall CE, Wood EG, Loschko J, et al. Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metabolism. 2018 Mar 6;27(3):588–601.e4. doi:10.1016/j.cmet.2018.02.007

Funding/Conflicts: Mixed Funding [Public: Public support came from the Medical Research Council (MRC) (MR/L002345/1) and the Medical College of Saint Bartholomew’s Hospital Trust, both of which are affiliated with publicly funded academic institutions. Non-profit funding included multiple grants from the British Heart Foundation (FS/13/49/30421, PG/16/79/32419, FS/14/66/31293), the Marie Curie / Cascade Fellowship (CF-2013-11-003-longhi); Non-Profit: Action Against Cancer and the Hilary Craft Foundation (PS8508). Additionally, one author was supported by a studentship from Bart’s and the London School of Medicine, a non-profit academic institution.] // No direct Conflicts of Interest

[A] Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes. 2007;56(4):1010-1013. doi:10.2337/db06-1656

[B] Beasley LE, Koster A, Newman AB, et al. Inflammation and race and gender differences in computerized tomography-measured adipose depots. Obesity (Silver Spring). 2009;17(5):1062-1069. doi:10.1038/oby.2008.627

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#visceralfat #nutritiontips

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:20 - Dendritic Cells & Inflammation
4:05 - Visceral Fat, Beta-Catenin, and your Health
6:52 - Visceral Fat reduces Inflammation??
9:15 - How do we preserve Beta-Catenin?
11:18 - Main Points

References
[Study 506] Macdougall CE, Wood EG, Loschko J, et al. Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metabolism. 2018 Mar 6;27(3):588–601.e4. doi:10.1016/j.cmet.2018.02.007

Funding/Conflicts: Mixed Funding [Public: Public support came from the Medical Research Council (MRC) (MR/L002345/1) and the Medical College of Saint Bartholomew’s Hospital Trust, both of which are affiliated with publicly funded academic institutions. Non-profit funding included multiple grants from the British Heart Foundation (FS/13/49/30421, PG/16/79/32419, FS/14/66/31293), the Marie Curie / Cascade Fellowship (CF-2013-11-003-longhi); Non-Profit: Action Against Cancer and the Hilary Craft Foundation (PS8508). Additionally, one author was supported by a studentship from Bart’s and the London School of Medicine, a non-profit academic institution.] // No direct Conflicts of Interest

[A] Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes. 2007;56(4):1010-1013. doi:10.2337/db06-1656

[B] Beasley LE, Koster A, Newman AB, et al. Inflammation and race and gender differences in computerized tomography-measured adipose depots. Obesity (Silver Spring). 2009;17(5):1062-1069. doi:10.1038/oby.2008.627

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#visceralfat #nutritiontips

Mindsip insights from this episode:

Understand visceral fat's role in inflammation through WNT10 signaling

Visceral fat tissue communicates with immune cells by releasing a protein called WNT10, which in turn controls beta-catenin levels and inflammation.

Avoid Western diet to enhance anti-inflammatory signals

A Western diet, rich in sugar and saturated fats, reduces WNT10 release from visceral fat, which lowers beta-catenin and increases inflammation.

Activate Frizzled and Disheveled to combat inflammation

The pathway that protects beta-catenin involves proteins with humorous names, where a signal binds to a receptor called "Frizzled," which then activates a protein called "Disheveled.".

Leverage beta-catenin to regulate inflammation

A protein called beta-catenin, while not common in clinical discussions, plays a powerful role in keeping inflammation throughout your body in check.

Investigate human links between beta-catenin, WNT, and visceral fat inflammation

While the mechanism is shown in animal studies, there is currently little good research directly linking beta-catenin and WNT from visceral fat to inflammation in humans.

Recognize immune cells in visceral fat to manage inflammation

Your visceral fat tissue contains immune cells, specifically a subpopulation called dendritic cells that can activate a pro-inflammatory response.

Activate beta-catenin to reduce inflammation in dendritic cells

Activating beta-catenin in dendritic cells dramatically reduces the release of pro-inflammatory molecules like Interleukin 6 (IL-6).

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© Mindsip 2025 – Made with ❤ in Vilnius

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© Mindsip 2025 – Made with ❤ in Vilnius