Anti-Aging Secrets Of The World's Longest-Lived Woman, The Top Longevity "Drugs", Fat Loss & Muscle Gain Tips & Much More! Q&A 494
Ben Greenfield
Oct 30, 2025
Mindsip insights from this episode:
Microdose GLP-1 to reduce neuroinflammation and food noise
The host microdoses the GLP-1 drug Retatrutide not for weight loss, but to quiet 'food noise' and reduce neuroinflammation.
Select hyperbaric chamber based on inflammation type
Soft-shell hyperbaric chambers are more effective for chronic inflammation (TNF-alpha, IL-6), while hard-shell chambers are better for cardiovascular inflammation (myeloperoxidase).
Beware statins for potential GLP-1 reduction and insulin resistance
Recent research in Cell Metabolism shows statins can worsen insulin resistance by reducing the body's natural levels of the hormone GLP-1.
Disable PWM on iPhone 17 to reduce eye strain
The new iPhone 17 has a setting to disable pulse width modulation (PWM), which can reduce screen flicker and associated eye strain or headaches.
Prioritize telomere shortening rate over length for longevity insights
The world's oldest woman had short telomeres, suggesting the rate of shortening is a more important longevity metric than their absolute length.
Implement peptide protocol with Epitalon to elongate telomeres
The peptide Epitalon, identified as a top anti-aging compound, is used in a 10-day course twice a year to help elongate telomeres.
Recognize high LDL cholesterol as potential protective factor
The world's longest-living woman had high LDL cholesterol, which may have been protective in the absence of other risk factors like inflammation or high blood glucose.
Build muscle in a calorie deficit with high protein intake
It is possible to build muscle while in a calorie deficit as long as protein intake is high, debunking the myth that you must eat a surplus to gain muscle.
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