Anti-Aging Secrets Of The World's Longest-Lived Woman, The Top Longevity "Drugs", Fat Loss & Muscle Gain Tips & Much More! Q&A 494

Ben Greenfield

Oct 30, 2025

Episode description

Full Show Notes: https://bengreenfieldlife.com/494

In this episode, I dig into the fascinating story of the world’s oldest woman—a vibrant supercentenarian from Spain who made it to 117 years old. I break down what researchers discovered about her genes, lifestyle, and daily habits (you might be surprised by some of the things she ate and didn’t do!).

I also get nerdy about the newest longevity drugs and supplements—like curcumin, spermidine, taurine, and a few others you might not expect—and explain which ones actually work, according to the science in mammals. Plus, I share some updates from my own life, like the weirdly exciting health setting I just found on my new iPhone, and spill the beans on why I microdose alcohol (and sometimes other things) instead of going on a bender.

If you’re curious about muscle gain (do you really need to be in a calorie surplus?), soft-shell vs hardshell hyperbaric chambers, or how certain supplements might actually help you live longer, you’re in the right place. There’s a lot of info coming your way, and I’ve tried to translate all the geeky science into practical tips for you to use.

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LMNT: Everyone needs electrolytes, especially thos

Mindsip insights from this episode:

Microdose GLP-1 to reduce neuroinflammation and food noise

The host microdoses the GLP-1 drug Retatrutide not for weight loss, but to quiet 'food noise' and reduce neuroinflammation.

#GLP1

#microdosing

Select hyperbaric chamber based on inflammation type

Soft-shell hyperbaric chambers are more effective for chronic inflammation (TNF-alpha, IL-6), while hard-shell chambers are better for cardiovascular inflammation (myeloperoxidase).

#hyperbaric

#inflammation

Beware statins for potential GLP-1 reduction and insulin resistance

Recent research in Cell Metabolism shows statins can worsen insulin resistance by reducing the body's natural levels of the hormone GLP-1.

#GLP1

#statin

Disable PWM on iPhone 17 to reduce eye strain

The new iPhone 17 has a setting to disable pulse width modulation (PWM), which can reduce screen flicker and associated eye strain or headaches.

#screen-time

Prioritize telomere shortening rate over length for longevity insights

The world's oldest woman had short telomeres, suggesting the rate of shortening is a more important longevity metric than their absolute length.

#longevity

#telomeres

Implement peptide protocol with Epitalon to elongate telomeres

The peptide Epitalon, identified as a top anti-aging compound, is used in a 10-day course twice a year to help elongate telomeres.

#anti-aging

#peptides

Recognize high LDL cholesterol as potential protective factor

The world's longest-living woman had high LDL cholesterol, which may have been protective in the absence of other risk factors like inflammation or high blood glucose.

#LDL

#longevity

Build muscle in a calorie deficit with high protein intake

It is possible to build muscle while in a calorie deficit as long as protein intake is high, debunking the myth that you must eat a surplus to gain muscle.