Being Fat increases Autophagy - shocking, I know. [Study 236 - 240]
Physionic
Jan 1, 2024
Mindsip insights from this episode:
Recognize overeating's role in increasing autophagy
Multiple studies show that overeating, leading to obesity, results in a dramatic increase in the autophagy marker LC3, challenging the idea that only fasting induces autophagy.
Utilize autophagy to combat inflammation by targeting cytokines
An alternative explanation is that autophagy is upregulated to combat inflammation by enveloping and destroying inflammatory proteins like cytokines within the cell.
Recognize overweight status as a factor in increased autophagy
Contrary to the popular narrative focused on fasting, being overweight or obese has been shown to significantly increase autophagy markers in fat tissue.
Enhance autophagy in type 2 diabetes for better fat tissue health
The increase in autophagy is even more pronounced in the subcutaneous fat tissue of individuals with type 2 diabetes compared to those who are obese but not diabetic.
Clarify autophagy's role: no cell death observed
Despite high autophagy levels, this process does not appear to be causing cell death, as researchers found no increase in the active, cleaved form of caspase proteins.
Reconsider autophagosomes as cellular escorts for protein movement
A novel theory suggests autophagosomes may not destroy cellular contents but instead act like escorts, moving large chunks of proteins to clear space within the cell.
Utilize autophagy to enhance fat cell creation
The increased autophagy in fat tissue may be a mechanism to facilitate adipogenesis, the process of creating new fat cells, by helping the mother cell divide.
More from
Physionic
You also might be interested in
Male vs. Female Brain Differences & How They Arise From Genes & Hormones | Dr. Nirao Shah
Peter’s takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6
Boost Brain Power by 25% WITHOUT a Pill (Brain Optimization Secrets)
The Biohacking Tool That Will Change the World (Mitochondrial Transfusions)
Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway)
