Being Fat increases Autophagy - shocking, I know. [Study 236 - 240]

Physionic

Jan 1, 2024

Episode description

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REFERENCES (Copy & Paste DOI into Search Engine)
[1] [Study 236] doi:10.1080/15548627.2017.1378838
[2] [Study 237] doi:10.1210/jc.2010-1681
[3] [Study 238] doi:10.1016/j.mce.2015.03.015
[4] [Study 239] doi:10.1007/s00125-014-3255-3
[5] [Study 240] doi:10.17179/excli2018-1353

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#autophagy #healthscience

Episode description

Mindsip insights from this episode:

Recognize overeating's role in increasing autophagy

Multiple studies show that overeating, leading to obesity, results in a dramatic increase in the autophagy marker LC3, challenging the idea that only fasting induces autophagy.

#autophagy

#obesity

Utilize autophagy to combat inflammation by targeting cytokines

An alternative explanation is that autophagy is upregulated to combat inflammation by enveloping and destroying inflammatory proteins like cytokines within the cell.

#autophagy

#inflammation

Recognize overweight status as a factor in increased autophagy

Contrary to the popular narrative focused on fasting, being overweight or obese has been shown to significantly increase autophagy markers in fat tissue.

#autophagy

#obesity

Enhance autophagy in type 2 diabetes for better fat tissue health

The increase in autophagy is even more pronounced in the subcutaneous fat tissue of individuals with type 2 diabetes compared to those who are obese but not diabetic.

#autophagy

#diabetes

Clarify autophagy's role: no cell death observed

Despite high autophagy levels, this process does not appear to be causing cell death, as researchers found no increase in the active, cleaved form of caspase proteins.

#autophagy

Reconsider autophagosomes as cellular escorts for protein movement

A novel theory suggests autophagosomes may not destroy cellular contents but instead act like escorts, moving large chunks of proteins to clear space within the cell.

#autophagy

#cells

Utilize autophagy to enhance fat cell creation

The increased autophagy in fat tissue may be a mechanism to facilitate adipogenesis, the process of creating new fat cells, by helping the mother cell divide.