
Can we reverse Atherosclerosis? [Study 241 - 246 Analysis]
Physionic
Jan 31, 2024
Mindsip insights from this episode:
Understand atherosclerosis formation through LDL and proteoglycans
Atherosclerosis begins when the APOB protein on LDL particles is electrostatically attracted to oppositely charged proteoglycan proteins in the artery wall, causing the LDL to get stuck.
Measure APOB for comprehensive cardiovascular risk assessment
For a more accurate assessment of cardiovascular risk, it is better to measure APOB in totality, as this single marker accounts for all atherogenic particles, not just LDL.
Implement HIIT to reverse atherosclerosis
A six-month study on individuals with cardiovascular disease found that high-intensity interval training (HIIT) led to a statistically significant decrease in plaque volume compared to a control group.
Utilize HDL particles for effective plaque reversal
HDL particles can aid in plaque reversal by picking up cholesterol molecules and crystals directly from the plaque and transporting them back to the liver.
Lower LDL/APOB levels to enable plaque reversal
Plaque reversal is theoretically possible by lowering LDL/APOB levels enough to create a concentration gradient where more lipoproteins leave the plaque than enter it.
Understand how arteries transform into bone in advanced atherosclerosis
In advanced atherosclerosis, smooth muscle cells can de-differentiate and start acting like bone cells, depositing calcium into the plaque, which is what a CAC score measures.
Recognize LDL's role in plaque formation despite healthy endothelium
Even with a perfectly healthy endothelium, high levels of LDL can still lead to plaque formation as the particles can pass directly through the endothelial cells themselves.
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