Could *This* Molecule Be the KEY To Reversing Immune Aging & “Supercharging” Your Mitochondria? With Dr. Anurag Singh
Ben Greenfield
Jun 4, 2026
Episode description
Full Show Notes: https://bengreenfieldlife.com/timelinereplay
In this special replay episode with repeat guest Dr. Anurag Singh from Timeline Nutrition, you'll explore the science of cellular health and longevity, including why mitochondrial function affects everything from energy and muscle performance to cognitive clarity and how well you age. Dr. Singh explains how urolithin A, a postbiotic compound derived from foods like pomegranates and berries, activates mitophagy, the body's cellular clean-up system that clears out worn-out mitochondria and replaces them with new ones, and how clinical research shows it can support muscle strength, endurance, immune resilience, and cognitive function. You'll also hear how diet, gut health, exercise, sleep, and recovery work alongside urolithin A to build a stronger, more resilient physiology over time.
Dr. Anurag Singh is Chief Medical Officer at Timeline Nutrition, with an M.D. in internal medicine and a Ph.D. in immunology. He has authored more than 50 scientific articles, been awarded over 20 patents, and led more than 50 randomized clinical trials. His decade of research on urolithin A has produced multiple clinically validated products bringing longevity science directly to consumers.
Episode Sponsors:
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Troscriptions: A buccal troche delivery system that bypasses digestion to deliver pharmaceutical-grade compounds directly through your cheek mucosa for faster onset and higher bioavailability. Visit troscriptions.com/BEN or use code BEN for 10% off your first order.
Timeline: High-performance products powered by Mitopure, delivering a precise dose of urolithin A for healthy aging. Mitopure starts at $79 at timeline.com/BEN.
Just Thrive: The Gut Essentials Bundle pairs a probiotic clinically proven to arrive 100% alive in your gut with Digestive Bitters, a blend of 12 science-backed herbs. Visit
Mindsip insights from this episode:
Reverse immune aging with Urolithin A daily
A recent clinical trial showed that 1 gram of Urolithin A daily reversed markers of immune aging in 50-year-olds, making their immune systems resemble those of a 30-40 year old.
Address immune aging to combat aging hallmarks
The speaker's unique philosophy is that immune aging is the central trigger for many other hallmarks of aging because immune cells police every organ in the body.
Utilize urolithin A to modulate immune response
Urolithin A acts as an immune modulator, strengthening a weak immune system while also reining in an overreactive one to maintain homeostasis.
Supplement to achieve optimal Urolithin A levels due to gut microbiome bottleneck
Only about 1 in 10 Americans have the right gut microbiome to naturally convert precursors from food into Urolithin A, making supplementation necessary for most.
Optimize Urolithin A dosage for systemic benefits
The 1-gram dose of Urolithin A was found to be the sweet spot for systemic benefits like lowering C-reactive protein (CRP), with effects plateauing at 2 grams.
Juice 60 pomegranates to achieve effective Urolithin A dose
To get the clinically effective 1-gram dose of Urolithin A from food, you would need to juice the equivalent of 60 pomegranates.
Enhance mitochondrial health through biogenesis, efficiency, and mitophagy
You can improve mitochondrial health via three distinct mechanisms: biogenesis (exercise, fasting), efficiency (creatine, CoQ10), and mitophagy or cellular cleanup (Urolithin A).
Utilize Urolithin A and tirzepatide to recharge cancer-fighting CAR T-cells
A new study found that Urolithin A and the GLP-1 drug tirzepatide were the only two compounds out of 8,000 tested that could recharge cancer-fighting CAR T-cells.
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