Doctor's Concerns About Testosterone Therapy Abuse
Brad Stanfield
Feb 21, 2025
Episode description
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Here are the links to the research papers referenced in the video:
https://www.uptodate.com/contents/clinical-features-and-diagnosis-of-male-hypogonadism
https://pmc.ncbi.nlm.nih.gov/articles/PMC3064036/
https://pubmed.ncbi.nlm.nih.gov/9024227/
https://pubmed.ncbi.nlm.nih.gov/9253305/
https://pubmed.ncbi.nlm.nih.gov/26886521/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11562514/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7880314/
https://pubmed.ncbi.nlm.nih.gov/28241355/
https://pmc.ncbi.nlm.nih.gov/articles/PMC5690890/
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-cautions-about-using-testosterone-products-low-testosterone-due
https://www.uptodate.com/contents/approach-to-older-males-with-low-testosterone
https://www.nejm.org/doi/full/10.1056/NEJMoa2215025
https://www.jacc.org/doi/10.1016/j.jacadv.2023.100742
https://academic.oup.com/jcem/article-abstract/95/4/1810/2597149
Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.
Mindsip insights from this episode:
Address obesity to reduce low testosterone risk
A study found that a BMI of over 30 was associated with a nearly nine times higher risk of having low testosterone.
Boost testosterone and athletic performance with betaine
Betaine, also known as TMG, is a supplement that has good evidence for boosting testosterone and athletic performance.
Address root causes before considering testosterone therapy
Before considering testosterone therapy, one should first address root causes like obesity and chronic illness and implement resistance exercise.
Evaluate testosterone therapy risks for heart health
Despite positive headlines, the new Transverse Trial's data allows for the possibility that testosterone therapy could increase heart problems by as much as 17%.
Critique testosterone study due to high dropout rate
The recent Transverse Trial on testosterone safety is controversial because 62% of participants in the treatment group stopped the therapy before the study was over.
Monitor red blood cell levels to manage TRT side effects
The most common adverse effect of testosterone therapy is an increase in red blood cells, a condition called eryrocytosis, which can lead to higher blood pressure.
Reserve testosterone therapy for clinical needs only
Clinical guidelines recommend testosterone therapy only for men with clinically low levels and accompanying symptoms, not for normal age-related decline.
