
Does Lp(a) cause Heart Disease? Are there Solutions? [Study 251-265 Analysis]
Physionic
Mar 13, 2024
Mindsip insights from this episode:
Address Lp(a) to prevent leaky blood vessels and plaque formation
Lp(a) can cause the cells lining your blood vessels to shrink, creating gaps that allow more harmful particles to enter the vessel wall and form plaque.
Manage Lp(a) levels to prevent stubborn blood clots
Lipoprotein(a) can bind to fibrin and block its degradation, which promotes the formation of blood clots that can lead to heart attacks or strokes.
Understand Lp(a) role in blocking protective proteins to prevent plaque formation
By blocking the enzyme plasmin, Lp(a) reduces levels of the mature TGF-beta protein, which normally prevents smooth muscle cells from migrating and contributing to plaque.
Recognize Lp(a) oxidation risk to manage inflammation
The unique linkage between the ApoA and ApoB proteins makes the Lp(a) particle more susceptible to oxidation than regular LDL, increasing its inflammatory potential.
Monitor Lp(a) levels to assess cardiovascular disease risk
A meta-analysis of 36 studies suggests that cardiovascular disease risk does not significantly increase until Lp(a) levels are above approximately 30-48 mg/dL.
Recognize Lp(a) as independent risk factor for coronary heart disease
In a study of individuals with low LDL cholesterol, those with high Lp(a) still had a significantly higher risk of coronary heart disease, highlighting it as an independent risk factor.
Achieve 94% reduction in Lp(a) with new siRNA therapy
A small interfering RNA (siRNA) therapy trial demonstrated a staggering 94% reduction in Lp(a) levels with a 75mg dose taken just once every 12 weeks.
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