Does Lp(a) cause Heart Disease? Are there Solutions? [Study 251-265 Analysis]

Physionic

Mar 13, 2024

Episode description

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Created with Biorender
Studies & Study Notes: TBA

0:00 - Introduction
1:26 - Covered Topics
3:06 - Mechanisms of Action [Studies 251, 262]
27:25 - Is Lp(a) a Heart Disease Risk?
28:43 - Lp(a) on Non-cardiac and Cardiac Death [Study 253]
46:40 - Lp(a) Gene Mutations [Study 255]
50:15 - Is Lp(a) independent of LDL risk?
51:08 - Lp(a) in Statin Users [Study 263]
1:04:18 - Lp(a) association with CVD risk [Study 264]
1:11:55 - Lp(a) when LDL is low [Study 265]
1:22:46 - ASO & siRNA Therapies for lowering Lp(a)
1:23:49 - ASO Therapy for reducing Lp(a) [Study 257]
1:33:52 - siRNA Therapy for reducing Lp(a) [Study 258]
1:42:37 - Side Effects of this Therapy
1:45:02 - Mid-Point Conclusion

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#Lpa #heartdiseaseawereness #heartdiseaseprevention

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H


Created with Biorender
Studies & Study Notes: TBA

0:00 - Introduction
1:26 - Covered Topics
3:06 - Mechanisms of Action [Studies 251, 262]
27:25 - Is Lp(a) a Heart Disease Risk?
28:43 - Lp(a) on Non-cardiac and Cardiac Death [Study 253]
46:40 - Lp(a) Gene Mutations [Study 255]
50:15 - Is Lp(a) independent of LDL risk?
51:08 - Lp(a) in Statin Users [Study 263]
1:04:18 - Lp(a) association with CVD risk [Study 264]
1:11:55 - Lp(a) when LDL is low [Study 265]
1:22:46 - ASO & siRNA Therapies for lowering Lp(a)
1:23:49 - ASO Therapy for reducing Lp(a) [Study 257]
1:33:52 - siRNA Therapy for reducing Lp(a) [Study 258]
1:42:37 - Side Effects of this Therapy
1:45:02 - Mid-Point Conclusion

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#Lpa #heartdiseaseawereness #heartdiseaseprevention

Mindsip insights from this episode:

Address Lp(a) to prevent leaky blood vessels and plaque formation

Lp(a) can cause the cells lining your blood vessels to shrink, creating gaps that allow more harmful particles to enter the vessel wall and form plaque.

Manage Lp(a) levels to prevent stubborn blood clots

Lipoprotein(a) can bind to fibrin and block its degradation, which promotes the formation of blood clots that can lead to heart attacks or strokes.

Understand Lp(a) role in blocking protective proteins to prevent plaque formation

By blocking the enzyme plasmin, Lp(a) reduces levels of the mature TGF-beta protein, which normally prevents smooth muscle cells from migrating and contributing to plaque.

Recognize Lp(a) oxidation risk to manage inflammation

The unique linkage between the ApoA and ApoB proteins makes the Lp(a) particle more susceptible to oxidation than regular LDL, increasing its inflammatory potential.

Monitor Lp(a) levels to assess cardiovascular disease risk

A meta-analysis of 36 studies suggests that cardiovascular disease risk does not significantly increase until Lp(a) levels are above approximately 30-48 mg/dL.

Recognize Lp(a) as independent risk factor for coronary heart disease

In a study of individuals with low LDL cholesterol, those with high Lp(a) still had a significantly higher risk of coronary heart disease, highlighting it as an independent risk factor.

Achieve 94% reduction in Lp(a) with new siRNA therapy

A small interfering RNA (siRNA) therapy trial demonstrated a staggering 94% reduction in Lp(a) levels with a 75mg dose taken just once every 12 weeks.

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