Bryan Johnson does not use saunas because the available evidence did not cross his team's threshold for proving it slows the speed of aging or reverses aging damage.

To avoid public criticism, reframe intense health optimization as being a 'professional rejuvenation athlete,' which makes the dedication respectable, similar to how a sports figure like LeBron James is admired.

View criticism from others not as a personal attack but as a predictable, algorithmic, biochemical reaction to any behavior that falls outside of established societal norms.

Aim to be respected by people in the 25th century rather than your current peers, as seeking approval now incentivizes you to adopt ideas from the past.

To generate original ideas, disregard your first four thoughts on any topic as they are likely just parroting societal norms, and aim for the fifth thought which might actually be interesting.

A 90-day self-experiment measuring intracellular NAD levels showed that both NR and NMN were equally effective, suggesting the debate between them may be unnecessary for achieving results.

To counteract the testosterone-lowering effects of a calorie-restricted diet, Bryan Johnson uses testosterone patches to maintain his levels around 900.

Psychedelics can be used as a tool to populate your mental map with the full range of conscious experiences your brain is capable of, changing your perception of what is possible.

For treating hair loss, the protocol is moving away from Platelet-Rich Plasma (PRP) and is now exploring Tixel, a thermal-mechanical device, to enhance the delivery of exosomes to the scalp.