A future game-changer in biotech could be a non-androgenic anabolic drug that builds muscle mass without the side effects of steroids by targeting pathways like myostatin.

A primary motivation for bodybuilding can be pure aesthetics, treating one's body as a personal sculpture to be perfected for artistic satisfaction.

A key motivation for using steroids is the 'comic book' excitement of using pharmaceuticals to upgrade your own body's abilities.

Bryan Johnson stopped taking rapamycin after four years due to negative side effects like disrupted lipids, increased resting heart rate, and a new preprint suggesting it may accelerate some aging clocks.

The primary goal isn't to achieve immortality, but simply to not die in the near future to witness the profound, reality-altering changes promised by AI and biotech.

High-level physique and longevity enthusiasts avoid seemingly trivial physical feats like arm wrestling because the risk of a minor injury derailing long-term goals is not worth the benefit.

Using aesthetics and the desire to look younger is a 'cheater way' to get people interested in longevity, as it's a more immediate and relatable motivator than the abstract concept of living longer.

The new class of anti-obesity drugs like Ozempic is the first tangible sign of a coming biotech revolution that will make managing body weight as simple as turning a dial.