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0:00 - Introduction
0:55 - Murmurings of Benefit
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5:40 - Incredible Results
7:56 - I was Right in 2023
10:19 - Useless for Most...

References
[Study 117] Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022;14(5):1114. Published 2022 Mar 7. doi:10.3390/nu14051114

Funding/Conflict : Public: none reported; Non-Profit: internal institutional funding from Baylor College of Medicine supported this pilot project; Industry: no industry funding reported; Conflicts of interest: the authors state that they have no conflicts of interest.

[Study 118] Kumar P, Liu C, Hsu JW, et al. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021;11(3):e372. doi:10.1002/ctm2.372

Funding/Conflict : Public: no public or governmental funding was reported; Non-Profit: the study was supported by a philanthropic gift from the McNair Medical Institute at the Robert and Janice McNair Foundation in Houston, Texas, USA; Industry: no industry or commercial funding was reported; Conflicts of interest: the authors report that none of them have any conflicts of interest to disclose.

[Study 119] Kumar P, Liu C, Suliburk J, et al. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2023;78(1):75-89. doi:10.1093/gerona/glac135

Funding/Conflict : Public funding: R01AG041782 from the U.S. National Institutes of Health / National Institute on Aging was awarded to R.V.S. to support this work; Non-profit funding: a philanthropic research gift to R.V.S. from the McNair Medical Institute at the Robert and Janice McNair Foundation in Houston, Texas provided additional support; Industry funding: no industry funding was reported; Conflicts of interest: the authors state that these funders had no role in the trial conduct, data analysis, result interpretation, or manuscript preparation, and that no conflicts of interest were declared.

[Study 638] Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study. Antioxidants (Basel). 2022;11(1):154. Published 2022 Jan 13. doi:10.3390/antiox11010154

Funding/Conflict : Public: none reported; Non-Profit: seed funding from Baylor College of Medicine to the author (R.V. Sekhar) supported this work; Industry: no industry or commercial funding was reported; Conflicts of interest: the author states that there are no conflicts of interest.

[Study 639] Kumar P, Osahon OW, Sekhar RV. GlyNAC (glycine and N-acetylcysteine) supplementation in old mice improves brain glutathione deficiency, oxidative stress, glucose uptake, mitochondrial dysfunction, genomic damage, inflammation and neurotrophic factors to reverse age-associated cognitive decline: implications for improving brain health in aging. Antioxidants (Basel). 2023;12(5):1042. doi:10.3390/antiox12051042

Funding/Conflict : Public: none reported; Non-Profit: this project received philanthropic support from the McNair Medical Institute at the Robert and Janice McNair Foundation; Industry: no industry or commercial funding was reported; Conflicts of interest: the authors declare that they have no conflict of interest.

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