How to Catch Alzheimer’s Before It Starts, with Dr. Eric Topol

Mark Hyman

Jul 23, 2025

Episode description

On this episode of The Doctor Hyman Show, I sit down with Dr. Eric Topol—renowned cardiologist, geneticist, and founder of the Scripps Research Translational Institute—to talk about the future of disease prevention. From AI diagnostics to genetic risk scoring, we explore the tools that could help stop Alzheimer’s and other chronic diseases before they start.

This is one of the most hopeful conversations I’ve had about what’s ahead. Watch it on YouTube here.

We discuss:

• How new diagnostics and AI tools could help detect Alzheimer’s early

• The key lab tests and biomarkers to know—and how to talk to your doctor about them

• Why tracking your health data over time matters more than you think

• What you can do to strengthen your immune system and lower disease risk

We have more power than ever to take control of our health. This episode shows you where to start.

View Show Notes From This Episode


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This episode is brought to you by Seed, Pique, fatty15 and AirDoctor. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman. Head to fatty15.com/hyman and use code HYMAN for 15% off your 90-day subscription Starter Kit.Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman.

Episode description

On this episode of The Doctor Hyman Show, I sit down with Dr. Eric Topol—renowned cardiologist, geneticist, and founder of the Scripps Research Translational Institute—to talk about the future of disease prevention. From AI diagnostics to genetic risk scoring, we explore the tools that could help stop Alzheimer’s and other chronic diseases before they start.

This is one of the most hopeful conversations I’ve had about what’s ahead. Watch it on YouTube here.

We discuss:

• How new diagnostics and AI tools could help detect Alzheimer’s early

• The key lab tests and biomarkers to know—and how to talk to your doctor about them

• Why tracking your health data over time matters more than you think

• What you can do to strengthen your immune system and lower disease risk

We have more power than ever to take control of our health. This episode shows you where to start.

View Show Notes From This Episode


Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive



This episode is brought to you by Seed, Pique, fatty15 and AirDoctor. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman. Head to fatty15.com/hyman and use code HYMAN for 15% off your 90-day subscription Starter Kit.Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman.

Mindsip insights from this episode:

Limit protein intake to avoid atherosclerosis and inflammation

Consuming excessive amounts of protein, particularly animal protein, can be dangerous as it may promote atherosclerosis and inflammation, with no data supporting benefits beyond 1.6 grams per kilogram.

Enhance deep sleep by managing evening habits and stress

You can significantly increase deep sleep by avoiding late-night exercise and meals, limiting evening fluids, and managing stress, which can improve deep sleep from under 15 minutes to over 45 minutes a night.

Utilize P-tau217 blood test to detect Alzheimer's risk early

The P-tau217 blood test can detect the very first changes of Alzheimer's disease up to 20 years before mild cognitive impairment begins.

Utilize AI to detect disease risks in normal lab values

AI can analyze trends in your lab values, even when they are within the normal range, to flag risks for diseases like pancreatic cancer years in advance.

Utilize proteomic tests to measure organ aging

Inexpensive proteomic tests can now measure the biological age of eight specific organs, including the brain and heart, by analyzing thousands of plasma proteins.

Eliminate microplastics to reduce arterial inflammation and heart risks

A major study found that the presence of microplastics in arterial plaque is associated with vicious inflammation and a four to five-fold increase in heart attacks, strokes, and death.

Avoid metformin during resistance training to maximize muscle gains

Taking metformin while doing progressive resistance training may inhibit mitochondrial function and prevent you from getting the same muscle-building response compared to placebo.

Combat social isolation to reduce disease risk

There is significant data showing that social isolation is a risk factor for neurodegenerative diseases, cardiovascular problems, and even cancer.

Test GLP-1 drugs like Ozempic for brain inflammation in Alzheimer's trials

GLP-1 drugs like Ozempic are being tested in large Alzheimer's trials on thin people due to their potent ability to reduce brain inflammation, a novel use beyond diabetes or weight loss.

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