Nattokinase: Plaque Reversing Supplement, or Biased Science?

Physionic

Jun 10, 2024

Episode description

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References [Copy & Paste DOI into Search Engine]
[1] doi:10.3390/nu15194239
[2] doi:10.2147/IBPC.S99553
[3] doi:10.1291/hypres.31.1583
[4] doi:10.3389/fcvm.2022.964977
[5] doi:10.1089/jmf.2019.0183
[6] Lipid-Lowering Effect of Nattokinase in Patients with Primary Hypercholesterolemia (No DOI)
[7] doi.org/10.3233/CH-211147
[8] doi:10.1039/c8fo02324g
[9] PMID: 19786378

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#nattokinase #heartdiseaseprevention #heartdiseasetreatment

Episode description

Mindsip insights from this episode:

Utilize nattokinase for lowering high blood pressure only

Nattokinase supplementation appears to lower blood pressure only in individuals with pre-existing high blood pressure, showing no effect in those with normal levels.

#blood-pressure

#supplement

Understand nattokinase as a protease for blood clot management

Despite its name, nattokinase is not a kinase enzyme but a protease, meaning it works by degrading proteins like the fibrin that holds blood clots together.

#enzyme

#supplement

Utilize high-dose nattokinase to reverse atherosclerosis

A study using a high dose of nattokinase (11,000 FU) reported an impressive 21% reversal of atherosclerosis in just over one year.

#plaque

#supplement

Critique flawed pro-nattokinase study on plaque reversal

The study showing significant plaque reversal is scientifically questionable because it lacked a control group and had potential industry conflicts of interest.

#plaque

#research

Reevaluate nattokinase dosage for atherosclerosis management

In a well-controlled study, a typical low dose of nattokinase (2,000 FU) taken for three years did not reverse or slow atherosclerosis compared to a placebo.

#plaque

#supplement

Determine specific dosages for atherosclerosis treatment

The studies on atherosclerosis used a low dose of 2,000 fibrinolytic units (FU) and a high dose of almost 11,000 FU.

#cancer

#dosage

Dismiss nattokinase as a cholesterol-lowering tool

Across multiple studies, nattokinase showed no effect on lipoprotein particle numbers, suggesting it is not an effective tool for lowering cholesterol carriers.