
Nitric Oxide: The Powerful Mitochondrial Effects
Physionic
Mar 19, 2025
Mindsip insights from this episode:
Transform dietary nitrates into nitric oxide for health benefits
Dietary nitrates are converted to nitrites by oral bacteria in your mouth and then to nitric oxide in your stomach acid.
Incorporate natural nitrate sources like spinach and beets for health benefits
While the study used isolated nitrates, natural sources include spinach, beets, and celery, as well as cured meats like salami and smoked fish.
Boost mitochondrial energy by 23% with nitrates
In a randomized control trial, consuming nitrates for three days increased mitochondrial ATP (cellular energy) production by 23%.
Enhance mitochondrial efficiency with nitrate consumption
Nitrate consumption improves mitochondrial efficiency without stimulating mitochondrial biogenesis, meaning it enhances existing mitochondria rather than creating more.
Utilize nitric oxide to stabilize electrons and reduce free radicals
Nitric oxide slows the electron transport chain by competing with oxygen, which paradoxically stabilizes electrons and may reduce the formation of damaging free radicals.
Enhance mitochondrial efficiency by reducing proton leak with nitrates
Nitrates increase mitochondrial efficiency by reducing a protein called ANT, which in turn decreases "proton leak" and keeps the energy-producing gradient intact.
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