Nitric Oxide: The Powerful Mitochondrial Effects

Physionic

Mar 19, 2025

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:08 - Understanding Nitrates and Nitric Oxide
1:12 - Study Background
2:19 - What happens to Mitochondria?
4:29 - How Nitrates have this Mitochondrial Effect?
8:12 - An Unconventional Mechanism
10:19 - Take-Aways

Reference
[Study 422] Larsen FJ, Schiffer TA, Borniquel S, et al. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011;13(2):149-159. doi:10.1016/j.cmet.2011.01.004

Funding/Conflicts: Mixed Funding [Public Funding: Swedish Research Council; VINNOVA (CIDaT) / Non-Profit Funding: Swedish Heart and Lung Foundation; Torsten and Ragnar Söderbergs Foundation; European Union’s 7th Framework Program (Flaviola)] / No direct Conflicts of Interest]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#nitricoxide #mitochondrialhealth

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:08 - Understanding Nitrates and Nitric Oxide
1:12 - Study Background
2:19 - What happens to Mitochondria?
4:29 - How Nitrates have this Mitochondrial Effect?
8:12 - An Unconventional Mechanism
10:19 - Take-Aways

Reference
[Study 422] Larsen FJ, Schiffer TA, Borniquel S, et al. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011;13(2):149-159. doi:10.1016/j.cmet.2011.01.004

Funding/Conflicts: Mixed Funding [Public Funding: Swedish Research Council; VINNOVA (CIDaT) / Non-Profit Funding: Swedish Heart and Lung Foundation; Torsten and Ragnar Söderbergs Foundation; European Union’s 7th Framework Program (Flaviola)] / No direct Conflicts of Interest]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#nitricoxide #mitochondrialhealth

Mindsip insights from this episode:

Transform dietary nitrates into nitric oxide for health benefits

Dietary nitrates are converted to nitrites by oral bacteria in your mouth and then to nitric oxide in your stomach acid.

Incorporate natural nitrate sources like spinach and beets for health benefits

While the study used isolated nitrates, natural sources include spinach, beets, and celery, as well as cured meats like salami and smoked fish.

Boost mitochondrial energy by 23% with nitrates

In a randomized control trial, consuming nitrates for three days increased mitochondrial ATP (cellular energy) production by 23%.

Enhance mitochondrial efficiency with nitrate consumption

Nitrate consumption improves mitochondrial efficiency without stimulating mitochondrial biogenesis, meaning it enhances existing mitochondria rather than creating more.

Utilize nitric oxide to stabilize electrons and reduce free radicals

Nitric oxide slows the electron transport chain by competing with oxygen, which paradoxically stabilizes electrons and may reduce the formation of damaging free radicals.

Enhance mitochondrial efficiency by reducing proton leak with nitrates

Nitrates increase mitochondrial efficiency by reducing a protein called ANT, which in turn decreases "proton leak" and keeps the energy-producing gradient intact.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius