JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

JOIN THE COMMUNITY
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

EMAIL LIST
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

HIRE ME FOR CONSULTING:
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
1:05 - RXRa: You’re being Naughty
3:28 - Polyunsaturated Fats: Not so Good looking Now, eh?
5:47 - Many Holes in the Message

References
[Study 686] Meyer M, Grabherr F, Plattner C, et al. Metabolic stress sensing by epithelial RXRα links westernization of diet with Crohn’s disease. Cell Metab. 2026;38:1-17. doi:10.1016/j.cmet.2025.11.008

Funding/Conflict: Public Funding: From the accessible funding disclosure, this work was supported by the German Research Foundation (DFG), including individual grant SO1141/10-1 and Research Unit FOR5042, and by grant K126408 to F.S. Non-Profit Funding: From the accessible funding disclosure, support was also reported from the Austrian Society of Gastroenterology and Hepatology to L.M. and the European Crohn’s and Colitis Organisation (ECCO) to F.G. Industry Funding: From the accessible funding disclosure, I did not find any industry funding reported. Conflicts of Interest: From the study, the authors declared no competing interests.

[Study 687] Ananthakrishnan AN, Khalili H, Konijeti GG, et al. Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. Gut. 2014;63(5):776-784. doi:10.1136/gutjnl-2013-305304

[Study 688] Lev-Tzion R, Griffiths AM, Ledder O, Turner D. Omega-3 fatty acids (fish oil) for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2014;(2): CD006320. doi:10.1002/14651858.CD006320.pub4

Funding/Conflict: Public Funding: From the study, this work was supported by the National Institutes of Health through K24 DK098311, P01 CA87969, P30 DK043351, K08 DK064256, K23 DK091742, K23 DK099681, and UM1 CA176276. Non-Profit Funding: From the study, support was also reported from a Research Scholars Award of the American Gastroenterological Association, the Crohn’s and Colitis Foundation of America, and the Broad Medical Research Program of the Broad Foundation. Industry Funding: From the study, no industry funding was reported. Conflicts of Interest: From the study, Ashwin N. Ananthakrishnan reported serving on the scientific advisory boards of Prometheus Inc. and Janssen Inc.; James M. Richter reported being a consultant for Policy Analysis, Inc.; Andrew T. Chan reported consulting for Bayer HealthCare, Millennium Pharmaceuticals, Pfizer Inc., and Pozen Inc.; the other listed authors reported no disclosures.

[Study 689] Chan SSM, Luben R, Olsen A, et al. Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn’s disease. Aliment Pharmacol Ther. 2014;39:834-842. doi:10.1111/apt.12670

Funding/Conflict: Public Funding: From the study, public support was reported from The NHS Executive Eastern Region, an NIHR clinical lectureship for S.S.M.C., the European Commission (DG-SANCO), the International Agency for Research on Cancer, the Federal Ministry of Education and Research in Germany, the Dutch Ministry of Health, Welfare and Sports, Dutch ZON (Zorg Onderzoek Nederland), Statistics Netherlands, the Swedish Scientific Council, the Regional Government of Skane and Västerbotten, and the UK Medical Research Council; Non-Profit Funding: From the study, non-profit support was reported from The Sir Halley Stewart Trust, Crohn’s and Colitis UK, the Danish Cancer Society, German Cancer Aid, Dutch Prevention Funds, LK Research Funds, the World Cancer Research Fund, the Swedish Cancer Society, and Cancer Research UK; Industry Funding: From the study, no industry funding was reported; Conflicts of Interest: From the study, the declaration of personal interests was none.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.