Ozempic: A Weight Loss Miracle or Metabolic Menace? A Discussion with Dr. Tyna Moore & Calley Means

Mark Hyman

Apr 17, 2024

Episode description

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Like most things in life, when it comes to optimizing metabolic health, a nuanced perspective can help. Rather than viewing it as a black-and-white issue, we can take into consideration the big-picture social context we’re facing that encourages ultra-processed foods, obesity, and lifelong medication as well as the micro-level of what people are experiencing as individuals and understanding how to help them when all else fails. Today I’m thrilled to sit down with Dr. Tyna Moore and Calley Means for a grounded discussion that explores both sides of the spectrum, and everything in between. 

In this episode, we discuss:

  • The controversial discussion of GLP-1 agonists like Ozempic, weighing the pros and cons of these new drugs in treating obesity and metabolic crises (3:34)

  • Challenging the notion of treating obesity with drugs like Ozempic (10:35)

  • An unsettling revelation about the push for using Ozempic in children (12:04)

  • Digging deeper into GLP-1 research and some of the benefits (32:51)

  • Why are children being born metabolically challenged? (41:11)

  • Dr. Moore’s approach to using peptides with her patients and for her own crippling pain, and what they’ve seen (45:19)

  • How our current healthcare system lacks policies and support for behavior change (1:27)



While there are always differing views, we know for sure that our food and drug policies aren’t serving the best interests of creating sustainable, empowered health for the masses. I hope you’ll tune in to hear more from this comprehensive and lively discussion. 



This episode is brought to you by Rupa Health, Pendulum, ARMRA Colostrum, and One Skin.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Pendulum is offering listeners 20% off their first month’s subscription of Akkermansia for gut health. Visit PendulumLife.com and use code HYMAN.

Save 15% on your first order of ARMRA Colostrum and unlock the power of 400+ functional nutrients. Just visit TryARMRA.com/Mark or use code MARK.

Unlock your healthiest skin yet. Try OneSkin with 15% off your first purchase using code HYMAN15 at OneSkin.co today.

Episode description

View the Show Notes From This Episode

Get Free Weekly Health Tips from Dr. Hyman

Sign Up for Dr. Hyman’s Weekly Longevity Journal

Like most things in life, when it comes to optimizing metabolic health, a nuanced perspective can help. Rather than viewing it as a black-and-white issue, we can take into consideration the big-picture social context we’re facing that encourages ultra-processed foods, obesity, and lifelong medication as well as the micro-level of what people are experiencing as individuals and understanding how to help them when all else fails. Today I’m thrilled to sit down with Dr. Tyna Moore and Calley Means for a grounded discussion that explores both sides of the spectrum, and everything in between. 

In this episode, we discuss:

  • The controversial discussion of GLP-1 agonists like Ozempic, weighing the pros and cons of these new drugs in treating obesity and metabolic crises (3:34)

  • Challenging the notion of treating obesity with drugs like Ozempic (10:35)

  • An unsettling revelation about the push for using Ozempic in children (12:04)

  • Digging deeper into GLP-1 research and some of the benefits (32:51)

  • Why are children being born metabolically challenged? (41:11)

  • Dr. Moore’s approach to using peptides with her patients and for her own crippling pain, and what they’ve seen (45:19)

  • How our current healthcare system lacks policies and support for behavior change (1:27)



While there are always differing views, we know for sure that our food and drug policies aren’t serving the best interests of creating sustainable, empowered health for the masses. I hope you’ll tune in to hear more from this comprehensive and lively discussion. 



This episode is brought to you by Rupa Health, Pendulum, ARMRA Colostrum, and One Skin.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Pendulum is offering listeners 20% off their first month’s subscription of Akkermansia for gut health. Visit PendulumLife.com and use code HYMAN.

Save 15% on your first order of ARMRA Colostrum and unlock the power of 400+ functional nutrients. Just visit TryARMRA.com/Mark or use code MARK.

Unlock your healthiest skin yet. Try OneSkin with 15% off your first purchase using code HYMAN15 at OneSkin.co today.

Mindsip insights from this episode:

Address GLP-1 deficiency to regulate appetite and combat obesity

The appetite-regulating hormones leptin and ghrelin don't work properly if the peptide GLP-1 isn't present to activate their receptors, suggesting a potential GLP-1 deficiency in those with obesity.

Utilize GLP-1 agonist to reduce COVID deaths in diabetics

A 2022 study of type 2 diabetics hospitalized with COVID found that weekly semaglutide administration led to an 80% reduction in death and ICU admissions.

Utilize peptides to heal heart tissue and reverse heart failure

Certain peptides, including GLP-1 agonists, have been shown in studies to heal heart tissue and even reverse heart failure.

Microdose GLP-1 agonists to minimize side effects

By using compounded GLP-1 agonists at a fraction of the standard starting dose, it's possible to gain benefits while avoiding severe side effects like nausea, vomiting, and muscle loss.

Save on GLP-1 agonists with compounded peptides for $20 a month

Instead of paying over $1,000 a month for brand-name drugs, GLP-1 agonists can be obtained from compounding pharmacies for as little as $20 a month.

Combine strength training and high-protein diet to prevent muscle loss

The manufacturer's own studies show significant muscle loss occurs on these drugs unless you combine them with intense strength training 4-5 times a week and a high-protein diet.

Prioritize keto diet and exercise over Ozempic for obesity in Denmark

In Denmark, home to Ozempic's manufacturer, the government-subsidized standard of care for obesity is a keto diet and exercise, not the drug itself.

Utilize microdosed peptides to alleviate autoimmune pain

A doctor personally uses tiny, microdosed amounts of peptides to mitigate the crippling pain from her psoriatic arthritis, an autoimmune condition.

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