Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Andrew Huberman

Oct 7, 2024

Episode description

In this episode, Dr. Craig Koniver, M.D., a board-certified physician trained at Brown University and Thomas Jefferson University, discusses the therapeutic application of peptides and hormones for enhancing physical and mental health and performance.

We explore GLP-1 analogs for weight loss, BPC-157 for wound healing and reducing inflammation, as well as peptides that increase growth hormone, improve REM sleep, and enhance cognitive function. We also cover testosterone therapy, NAD, NMN, and NR supplementation, methylene blue for mitochondrial health, stem cell therapies, and supplements such as CoEnzyme Q10 and methylated B vitamins.

Additionally, we discuss effective dosages, sourcing, safety considerations, and the importance of working with knowledgeable physicians. Whether you're currently using peptides or exogenous hormones, or simply curious about their potential benefits and risks, this episode provides the scientific rationale behind how peptides function, their potential to enhance mental and physical health, and how they can optimize performance.

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*Dr. Craig Koniver*
Koniver Wellness: https://koniverwellness.com
Koniver Aesthetics: https://koniveraesthetics.com
Instagram: https://www.instagram.com/koniverwellness
LinkedIn: https://www.linkedin.com/in/craig-koniver-md-4bb100126

*Timestamps*
00:00:00 Dr. Craig Koniver
00:04:52 Sponsors: Joovv & BetterHelp
00:07:40 What is a Peptide?
00:09:37 GLP-1 Agonists, Semaglutide Weight Loss, Brain Health
00:15:49 GLP-1 Microdoses, Muscle Loss; Inflammation
00:18:43 BPC-157, Inflammation
00:23:27 BPC-157, Injection & Oral Forms; Injury Repair
00:28:43 Sourcing, Anabolic Steroids, Testosterone
00:34:48 Black & Gray Market, Compounding Pharmacies, Purity
00:38:20 Sponsor: AG1
00:39:51 Partnering with a Physician, LPS
00:43:00 BPC-157, Pentadeca Arginate (PDA); Side Effects & Doses
00:46:35 Ipamorelin, GHRP-6, Sleep, Appetite; Tool: Sleep & Growth Hormone
00:54:17 Tesamorelin, Sermorelin, CJC-1295; Stacking Peptides
00:58:45 Sponsor: Function & Eight Sleep
01:01:54 Coenzyme Q10 (CoQ10), Mitochondrial Health
01:05:16 Prescriptions, Physicians & Trust
01:14:09 Agency in Your Health
01:17:13 MK-677, Appetite
01:19:32 Hexarelin; Growth Hormone Secretagogues Dosing
01:21:10 Methylated B Vitamins, Homocysteine
01:24:47 Peptides for Sleep, Pinealon, Epitalon
01:31:03 Glycine, Liver Detoxification; Dosage
01:37:19 GLP-1, Compounding Pharmacies
01:39:03 Stem Cell Therapy, PRP
01:41:18 Thymosin Alpha-1, Cerebrolysin & Brain Health
01:44:17 Peptides for Cognitive Function, Methylene Blue, Doses
01:50:20 Covid, NAD Infusion, NMN & NR Supplements
01:57:13 Nutritional Deficiencies; NAD Dose & Regimen, NMN & NR
02:07:53 PT-141, Vyleesi, Libido; Nausea
02:10:57 FDA Approval & Removal, Pharmaceutical Companies
02:20:17 Positivity, Mindset & Health
02:26:23 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

#HubermanLab #Science #Health #Peptides #HormoneHealth #Longevity

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Mindsip insights from this episode:

Consider Pentadeca-arginate as a substitute for BPC-157

A new peptide called Pentadeca-arginate (PDA), which has a similar structure to BPC-157, is being used as a physician-prescribed substitute following the FDA's ban on compounding BPC-157.

#peptides

#supplement

Question prescriptions for off-label use in healthcare

The vast majority of medicines prescribed in America are used off-label, meaning they were never FDA-approved for the specific purpose for which they are being prescribed.

#healthcare

Leverage peptides to achieve goals and motivate healthy habits

A successful motivational strategy is to use tools like peptides to help a person achieve their goal first, as the win itself provides the motivation to adopt and maintain healthy lifestyle habits.

#motivation

#peptides

Microdose GLP-1s to prevent muscle loss during weight loss

By microdosing GLP-1 agonists like Tirzepatide and ensuring weight loss is 2 pounds or less per week, you can effectively prevent the significant muscle loss commonly associated with these drugs.

#GLP1

#muscle

Inject BPC-157 systemically for superior injury healing

Injecting BPC-157 systemically, such as in the abdomen, is more effective for healing injuries, even in specific joints like the elbow, than injecting it locally at the site of injury.

#healing

#supplement

Implement optimal NAD+ infusion protocol for enhanced health

The most effective NAD+ infusion protocol involves a loading phase of five 750mg intravenous treatments over ten days, followed by a once-a-month maintenance dose.

#NAD

#supplement

Utilize methylene blue to enhance cognition and assess mitochondrial function

A 10mg oral dose of methylene blue can act as a potent cognitive stimulant and oxygenator; if it doesn't turn your urine blue or green, it may indicate poor mitochondrial function.

#cognition

#methylene-blue

Boost REM sleep with Pinealon peptide and glycine combination

The peptide Pinealon, especially when combined with glycine, has been observed to dramatically increase rapid eye movement (REM) sleep, with benefits persisting even on nights it is not taken.

#REM

#supplement

Combine peptides for targeted fat loss with one injection

Combining peptides like Ipamorelin (for subcutaneous fat) and Tesamorelin (for visceral fat) allows you to target multiple goals with a single daily injection.