Popular Supplement Linked To Heart Disease

Brad Stanfield

Feb 27, 2024

Episode description

Many people take high-dose vitamin B3 supplements in various forms such as NMN, NR, nicotinamide, or niacin for longevity purposes. But a new study links Vitamin B3 to blood vessel inflammation and heart disease. Let's take a closer look.

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Here are the links to the research papers referenced in the video:
https://www.nature.com/articles/s41591-023-02793-8
https://www.uptodate.com/contents/low-density-lipoprotein-cholesterol-lowering-with-drugs-other-than-statins-and-pcsk9-inhibitors
https://www.sciencedirect.com/science/article/pii/S0735109718345601?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345839/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361580/
https://pubmed.ncbi.nlm.nih.gov/38374343/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702140/

The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Mindsip insights from this episode:

Avoid high-dose B3 to reduce mortality risk

A meta-analysis of niacin studies found that high-dose vitamin B3 appeared to increase all-cause death rates by approximately 10%.

#mortality

#vitamin-B

Choose modest vitamin B3 doses over mega-doses of NMN or NR

The speaker personally takes a modest 50mg dose of vitamin B3 but advises against the mega-doses of NMN or NR that are popular.

#supplement

#vitamin-B

Identify risks of heart disease linked to excess vitamin B3

A new study found that a metabolite from excess vitamin B3, known as 4Py, is associated with a higher chance of developing heart disease.

#heart

#vitamins

Question NMN and NR supplement efficacy through human absorption studies

The speaker believes NMN and NR companies won't fund human absorption studies because it could prove their products are just expensive forms of niacin.

#research

#supplement

Understand conversion of NMN and NR to niacin for effective supplementation

Popular longevity supplements NMN and NR may be almost fully converted into niacin by the gut microbiome before the body can use them.

#microbiome

#supplement

Reevaluate high-dose niacin for heart health risks

Despite being used for decades to lower cholesterol, large clinical trials showed high-dose niacin did not reduce heart disease and caused serious side effects.