For most patients, a recommended protein target is 1.2 grams per kilogram of *ideal* body weight per day to help preserve muscle mass during weight loss.

New medications like Tirzepatide, which combines GLP-1 and GIP agonists, appear to be even more effective for weight loss and blood sugar control than GLP-1 drugs like Ozempic.

One study found that eating an extra 14 grams of fiber per day was associated with a 10% decrease in calories consumed, leading to significant weight loss.

For every one kilogram of weight lost, patients with type 2 diabetes saw a 0.1 percentage point drop in their HbA1c levels, a measure of long-term blood sugar control.

Analyses of weight loss strategies show that much of the weight lost at the six-month mark is regained by twelve months, with about 80% of total weight lost being regained within five years.

An extensive analysis of weight loss strategies concluded that creating an energy deficit is the most important factor for weight loss, more so than the specific macronutrient composition of the diet.

Subcutaneous fat (under the skin) does not seem to cause insulin resistance, but visceral fat stored deep around the organs is strongly linked to it.

A 2022 study found no statistically significant difference in visceral fat loss between low-carb, unprocessed-carb, and whole-grain diets, as long as calories were restricted.