The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes

Dave Asprey

Feb 25, 2025

Episode description

Can You Mimic Fasting—Without Actually Fasting?

Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health.

Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food.

Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation.

For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating.

What You’ll Learn:

• The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours)

• The four fasting metabolites that extend life by 96%

• How Mimio mimics fasting benefits—without giving up food

• The real reason over-fasting destroys your metabolism and hormones

• Why traditional longevity drugs (Metformin, Rapamycin) fall short

• Can you build muscle and burn fat at the same time? The science of mTOR & AMPK

• Why Big Pharma doesn’t want you to know about this breakthrough

*** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE ***

Sponsors:

Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Mimio Instagram: https://www.instagram.com/mimiohealth/

• Mimio Website: https://mimiohealth.com/

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Mindsip insights from this episode:

Implement 36-hour fast for optimal lifespan and healthspan extension

Clinical research suggests the 'magical number' for achieving the best lifespan and healthspan extension from fasting is the 36-hour mark, typically done via alternate-day fasting.

#fasting

#longevity

Utilize oleoylethanolamide to suppress appetite and boost focus during fasting

Oleoylethanolamide (OEA), previously thought to be a satiety factor only when eating, is surprisingly highly upregulated during fasting to suppress appetite and enhance cognitive focus.

#appetite

#fasting

Leverage Mimeo to extend lifespan significantly

The natural fasting-mimicking supplement Mimeo extended lifespan in C. Elegans by 96%, significantly outperforming metformin (36%) and rapamycin (19%).

#longevity

#supplement

Revolutionize research with a top-down approach to longevity

Mimeo's research starts by studying human longevity programs like fasting to identify key molecules first, then confirms their effects in lower organisms, reversing the traditional research model.

#longevity

#research

Challenge FDA rules to protect access to natural supplements

Natural molecules like 1-methylnicotinamide are blocked from being sold as supplements in the US simply because a company once tried and failed to get them approved as a drug.

#supplement

Choose nicotinamide for optimal NAD production

Nicotinamide was chosen over other NAD precursors because it's the source for everything downstream, including NMN, NAD, and the highly beneficial molecule 1-methylnicotinamide.

#NAD

#supplement

Leverage Mimeo's four metabolites to enhance fasting benefits

The Mimeo formula is a synergistic combination of four key metabolites that increase during fasting: nicotinamide, spermidine, palmitoylethanolamide (PEA), and oleoylethanolamide (OEA).

#fasting

#supplement

Take Mimeo with meals to prevent post-meal inflammation

Taking Mimeo with a meal was shown to prevent the typical post-meal inflammation and metabolic chaos, instead creating an anti-inflammatory and antioxidant state.

#antioxidants

#supplement

Boost free testosterone by 50% with Mimeo supplementation

In a clinical case study with Cedar Sinai, eight weeks of Mimeo supplementation was shown to raise free testosterone levels by 50% and reduce biological age by 2.5 years.