The Science of Living Longer: Diet, Supplements, & Sleep | Bryan Johnson

Mark Hyman

Jul 10, 2024

Episode description

Believe it or not, data can empower you to live a longer, happier, and healthier life. In this episode, I’m joined by Bryan Johnson, a health optimization pioneer. Bryan shares his meticulous approach to tracking and measuring every aspect of his health to make informed lifestyle choices. We break down his structured diet, supplement regimen, and sleep optimization techniques, all designed to enhance longevity and well-being. 

In this episode, we discuss:

  • The importance of rigorous measurement and data-driven interventions to optimize health

  • Maximizing nutrient density and minimizing unnecessary calories

  • How chronic inflammation and insulin resistance drive disease and accelerate aging

  • The Blueprint program, a systematic approach to health optimization that others can follow, incorporating diet, exercise, sleep, and supplements



Don’t miss our fascinating discussion of the “don’t die” philosophy and how it could revolutionize our approach to health and aging.

View Show Notes From This Episode

Get Free Weekly Health Tips from Dr. Hyman

Sign Up for Dr. Hyman’s Weekly Longevity Journal

This episode is brought to you by Rupa Health, Butcher Box, Thrive Market, and Cymbiotika.

Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com.

ButcherBox is giving new members two pounds of wild-caught salmon for FREE plus $30 off. Visit ButcherBox.com/Farmacy and use code FARMACY30.

Head over to ThriveMarket.com/Hyman today to received 30% off your first order and a free gift up to $60.

Upgrade your supplement routine with Cymbiotika. Get 20% off with free shipping on all orders. Head to Cymbiotika.com and use code HYMAN.

Episode description

Believe it or not, data can empower you to live a longer, happier, and healthier life. In this episode, I’m joined by Bryan Johnson, a health optimization pioneer. Bryan shares his meticulous approach to tracking and measuring every aspect of his health to make informed lifestyle choices. We break down his structured diet, supplement regimen, and sleep optimization techniques, all designed to enhance longevity and well-being. 

In this episode, we discuss:

  • The importance of rigorous measurement and data-driven interventions to optimize health

  • Maximizing nutrient density and minimizing unnecessary calories

  • How chronic inflammation and insulin resistance drive disease and accelerate aging

  • The Blueprint program, a systematic approach to health optimization that others can follow, incorporating diet, exercise, sleep, and supplements



Don’t miss our fascinating discussion of the “don’t die” philosophy and how it could revolutionize our approach to health and aging.

View Show Notes From This Episode

Get Free Weekly Health Tips from Dr. Hyman

Sign Up for Dr. Hyman’s Weekly Longevity Journal

This episode is brought to you by Rupa Health, Butcher Box, Thrive Market, and Cymbiotika.

Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com.

ButcherBox is giving new members two pounds of wild-caught salmon for FREE plus $30 off. Visit ButcherBox.com/Farmacy and use code FARMACY30.

Head over to ThriveMarket.com/Hyman today to received 30% off your first order and a free gift up to $60.

Upgrade your supplement routine with Cymbiotika. Get 20% off with free shipping on all orders. Head to Cymbiotika.com and use code HYMAN.

Mindsip insights from this episode:

Achieve elite muscle mass with a vegan, calorie-restricted diet

Contrary to popular belief, he has demonstrated that a vegan, calorie-restricted diet can achieve top-percentile muscle mass, bone density, and cardiovascular fitness.

Utilize longevity drug stack for enhanced lifespan

He takes a combination of promising longevity drugs, including Metformin, Acarbose, Rapamycin, and the senolytic drug Dasatinib.

Fire your evening self to regain control over food choices

To break bad habits, he created a persona for his self-destructive evening self and 'fired' him from making food decisions, a psychological trick that gave him control.

Simplify your workout with basic exercises for all muscles

Despite his physique, his daily one-hour workout is basic, focusing on stretching every muscle, low-weight/reasonable-rep exercises, and cardio, without needing fancy equipment.

Address death as a critical problem to solve

His entire project began by looking for a problem to solve in the 'negative space' outside of mainstream ideas, leading him to be one of the first to seriously tackle death.

Correct posture to reverse brain aging by 13 years

He discovered that poor posture was contributing to intracranial pressure and white matter lesions in his brain, which he was able to reverse by the equivalent of 13 years through posture correction.

Prioritize sleep discipline for perfect rest

He achieved a perfect WHOOP sleep score for eight months straight by prioritizing sleep above all else, which included finishing all his meals by 11 AM.

Optimize every calorie for measurable benefits

His diet is ruthlessly optimized so that every single calorie consumed must have a specific, measurable, and beneficial function in the body.

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Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius