The Supplement That Reversed Aging in Human Trials, with Dr. Anurag Singh

Mark Hyman

Jun 25, 2025

Episode description

On this episode of The Dr. Hyman Show, I sit down with Dr. Singh—Chief Medical Officer at Timeline and a pioneer in mitochondrial science—to talk about what’s really driving fatigue, muscle loss, and accelerated aging. Together, we break down the simple, science-backed ways to support your cells so you can feel stronger.

You’ll learn:

• Why your mitochondria impact energy, metabolism, and how you age

• The role Urolithin A supports cellular renewal—and what that means for your strength

• How you can pair fasting, movement, and nutrients for better energy and recovery

• Why personalized strategies can support your energy, focus, and strength over time

This episode is packed with takeaways for boosting your cellular energy—and it’s one of the most practical conversations I’ve had on the science of longevity.

View Show Notes From This EpisodeGet Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcastSign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcastJoin the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detoxJoin the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hiveThis episode is brought to you by Seed, Pique, BON CHARGE, Paleovalley and Timeline. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Head to piquelife.com/hyman to get 20% off + a free beaker and frother today. Go to boncharge.com and use code DRMARK to save 15% on your PEMF mat today. Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today.


Episode description

On this episode of The Dr. Hyman Show, I sit down with Dr. Singh—Chief Medical Officer at Timeline and a pioneer in mitochondrial science—to talk about what’s really driving fatigue, muscle loss, and accelerated aging. Together, we break down the simple, science-backed ways to support your cells so you can feel stronger.

You’ll learn:

• Why your mitochondria impact energy, metabolism, and how you age

• The role Urolithin A supports cellular renewal—and what that means for your strength

• How you can pair fasting, movement, and nutrients for better energy and recovery

• Why personalized strategies can support your energy, focus, and strength over time

This episode is packed with takeaways for boosting your cellular energy—and it’s one of the most practical conversations I’ve had on the science of longevity.

View Show Notes From This EpisodeGet Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcastSign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcastJoin the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detoxJoin the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hiveThis episode is brought to you by Seed, Pique, BON CHARGE, Paleovalley and Timeline. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Head to piquelife.com/hyman to get 20% off + a free beaker and frother today. Go to boncharge.com and use code DRMARK to save 15% on your PEMF mat today. Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today.


Mindsip insights from this episode:

Identify sodium fluoride as a mitochondrial toxin

Exposing cells to sodium fluoride causes the mitochondria to become stressed, suggesting it is a mitochondrial toxin.

Boost strength and VO2 levels with Urolithin A supplement

In placebo-controlled trials, taking a Urolithin A supplement without changing diet or exercise results in a 10-12% improvement in strength and a 10% improvement in VO2 levels.

Address mitochondrial dysfunction to combat aging

Mitochondrial dysfunction and the resulting lack of energy is the central hallmark and root cause of aging, more fundamental than the other hallmarks.

Address mitochondrial damage to prevent inflammation cycle

Damaged mitochondria become leaky and release their own DNA into the body, which directly causes inflammation and creates a vicious cycle.

Leverage 3M axis for enhanced health through muscle, mitochondria, and microbiome

A new framework called the '3M axis' links muscle health, mitochondrial function, and the microbiome, which acts as a 'polypharmacy' producing beneficial compounds.

Increase gut bacteria for Urolithin A production in Americans

Only 10% of people in the US have the correct gut bacteria to naturally produce the beneficial postbiotic Urolithin A from food, compared to 40% of Europeans.

Clean mitochondria before boosting with NAD+ or CoQ10

Mitochondrial boosters like NAD+ or CoQ10 may only work effectively after you first clear out old, damaged mitochondria using a mitophagy-inducing compound like Mitopure.

Rejuvenate aging immune cells with Mitopure supplementation

New research shows that Mitopure (Urolithin A) supplementation can rejuvenate aging immune cells, making them more numerous and better at fighting infection.

Recognize mitochondrial damage from statin use

Even without causing muscle pain, statin medications damage mitochondria in the muscle biopsies of nearly everyone who takes them.

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© Mindsip 2025 – Made with ❤ in Vilnius