The Supplement That Reversed Aging in Human Trials, with Dr. Anurag Singh
Mark Hyman
Jun 25, 2025
Mindsip insights from this episode:
Identify sodium fluoride as a mitochondrial toxin
Exposing cells to sodium fluoride causes the mitochondria to become stressed, suggesting it is a mitochondrial toxin.
Boost strength and VO2 levels with Urolithin A supplement
In placebo-controlled trials, taking a Urolithin A supplement without changing diet or exercise results in a 10-12% improvement in strength and a 10% improvement in VO2 levels.
Address mitochondrial dysfunction to combat aging
Mitochondrial dysfunction and the resulting lack of energy is the central hallmark and root cause of aging, more fundamental than the other hallmarks.
Address mitochondrial damage to prevent inflammation cycle
Damaged mitochondria become leaky and release their own DNA into the body, which directly causes inflammation and creates a vicious cycle.
Leverage 3M axis for enhanced health through muscle, mitochondria, and microbiome
A new framework called the '3M axis' links muscle health, mitochondrial function, and the microbiome, which acts as a 'polypharmacy' producing beneficial compounds.
Increase gut bacteria for Urolithin A production in Americans
Only 10% of people in the US have the correct gut bacteria to naturally produce the beneficial postbiotic Urolithin A from food, compared to 40% of Europeans.
Clean mitochondria before boosting with NAD+ or CoQ10
Mitochondrial boosters like NAD+ or CoQ10 may only work effectively after you first clear out old, damaged mitochondria using a mitophagy-inducing compound like Mitopure.
Rejuvenate aging immune cells with Mitopure supplementation
New research shows that Mitopure (Urolithin A) supplementation can rejuvenate aging immune cells, making them more numerous and better at fighting infection.
Recognize mitochondrial damage from statin use
Even without causing muscle pain, statin medications damage mitochondria in the muscle biopsies of nearly everyone who takes them.
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